Dbfetch
ID OV305412; SV 1; linear; genomic DNA; STD; HUM; 14494 BP. XX AC OV305412; XX PR Project:PRJEB49636; XX DT 06-JAN-2022 (Rel. 144, Created) DT 06-JAN-2022 (Rel. 144, Last updated, Version 1) XX DE Homo sapiens HLA-DRB1 gene for MHC class II antigen, allele DE HLA-DRB1*04:08:01 XX KW . XX OS Homo sapiens (human) OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. XX RN [1] RA Lucas J., Lucas AM J.; RT ; RL Submitted (21-DEC-2021) to the INSDC. RL ANTHONY NOLAN RESEARCH INSTITUTE, 77C Fleet Road, London, NW3 2QU, United RL Kingdom XX DR MD5; 7db717d66a285bce7228b759d130bd94. XX FH Key Location/Qualifiers FH FT source 1..14494 FT /organism="Homo sapiens" FT /mol_type="genomic DNA" FT /clone="AN300656" FT /db_xref="taxon:9606" FT CDS join(146..245,8503..8772,12231..12512,13210..13320, FT 13793..13816,14445..14458) FT /codon_start=1 FT /transl_table=1 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /product="MHC class II antigen" FT /function="antigen presenting molecule" FT /protein_id="CAH1028204.1" FT /translation="MVCLKFPGGSCMAALTVTLMVLSSPLALAGDTRPRFLEQVKHECH FT FFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRAAV FT DTYCRHNYGVGESFTVQRRVYPEVTVYPAKTQPLQHHNLLVCSVNGFYPGSIEVRWFRN FT GQEEKTGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSLTSPLTVEWRARSE FT SAQSKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS" FT exon 146..245 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=1 FT intron 246..8502 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=1 FT exon 8503..8772 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=2 FT intron 8773..12230 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=2 FT exon 12231..12512 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=3 FT intron 12513..13209 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=3 FT exon 13210..13320 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=4 FT intron 13321..13792 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=4 FT exon 13793..13816 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=5 FT intron 13817..14444 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=5 FT exon 14445..14458 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=6 XX SQ Sequence 14494 BP; 3869 A; 2932 C; 3282 G; 4411 T; 0 other; tccaacacta gattacccaa tccacgagca aggaaatcag taacttcttc cctataattt 60 ggaatgtggg tggagagggg tcatagttct ccctgagtga gactcacctg ctcctctggc 120 ccctggtcct gtcctgttct ccagcatggt gtgtctgaag ttccctggag gctcctgcat 180 ggcagctctg acagtgacac tgatggtgct gagctcccca ctggctttgg ctggggacac 240 ccgacgtaag tgcacattgt gggtgctgac ctactatggg gtggggaaaa aagggagttg 300 tgttaacatt gtgcccaggc catgtccctt aagaaagtgt gacattttct tcagggattg 360 cccatcttta tcatatggat cccaaattat ttccaccaca aatggaactt ggctacttgc 420 cctattcatg agactgtgta aagggccttt gtacaggcca tgttttactt taaatctcta 480 ccaataaaac ctttgcatca catgtcctca gggtctttag aggatttaga aataaggatg 540 ctaaaataaa ttcctcatac agcacttccc tttatcatgt tgacttatgt cagacgaaac 600 aaggttttgt tttgaaaatt ttgtgggagt caaaggaatt caaagggtct ctcctagacg 660 atcctgtgtt gtcctccaca ggacctgtgg tgttggcccc tcttcctcat atgtgaggat 720 gtacccagtg gcctccccat tgtttccttt cttttttttc tgaactccag tgtttataaa 780 gcctgtatcc ctgtagcata tgtaggttct ctgacagaag ttatacttag tgctctttct 840 ttcttatggg gaaaaatccc tggatctgaa actgacatct ttagtacttg gagtcaccct 900 acaggtaaag accatttatg aggtattcat tggtgcctcc tcttgatcgg tctctcagac 960 ccctgaatac ttggatactc ctcaagaact taaggcatcc tctgaaaaac tggcccagat 1020 tagtgcttat tattaatctt ttataacctt tctatacttg tttctcctgc atgctctaac 1080 tagacatgac agaagagatt caactaacat aggataaatt atatgaaatt ctatttttgt 1140 aagtcaaaaa tagtcaaata ccagaaaatt aataatgttc aaactatata ctctgtgtgg 1200 ggttaccgag acgacgtgga cattgttcac atctaatagg gctgaaagtc aatgaagaag 1260 tcctggaaac tccttgtctt actggggtct tgtcctaaat ttcataggtt cacccatcat 1320 gccctcagct ttccttaatt agccatgtct gcttatctct acctccagtt tctctctatt 1380 tttccccagc tatgttgtca tcatttccag aaatctctaa aacttgcaaa gatccttagc 1440 actatgagat ccattgaaag agataatttt tttctttttg agacagggct tggttctgtc 1500 acccaggctg tagtgcagtg gtgtgatcta ggctcactgc aacctctgct tcccacgctc 1560 aagtgatcct ccctcctcag cctccagagt agcggagact acaggcaggc aaacatgtgc 1620 agctaatttt catgattttg ttagagatga gattttgcca tgttgcccag gctgttctta 1680 aactcctgga ctcaagcaat cctcctgcct tagcctccca atatgctagg attatagatg 1740 tgagccattg tgcccaggca aaaagagatg aaccttaatt taaaaatttc ctttttctta 1800 aatcactgtt tctctatctg tgaattcttc ttccaactag aaggaggaga aagaagaagt 1860 ttgcctgtat ttctcaccag gaggaggagt ctagtgtgat atcaaaatga aagagtgctg 1920 gagcttgatc cccttcttgc tttccaggat ccctgcagtg atcagttccc acaccctggt 1980 ttattcatgt aaagcacact tatttttttc agcagctact ctttactggg ctccattcta 2040 agttcaaatc attctatttg agtaagatag agagggtccc gactctcatg gaagttacac 2100 aagagtagag gagacagaca ctaacccaat aagcatttaa caaagaagaa aatgttagag 2160 agacatagtg cactgaagaa aagacatcag gtttgtgaaa aagagagaca tggattcact 2220 tactttggtt catatgctta ggcagctata actgagaaag tgacattcag ctgagacaac 2280 aaaataaata gacagtcgtg aagatctaaa ggacgaaagt tccagggaga atgaatgggg 2340 gggaagctct ggtgtgggaa attatgtgga aggacagaaa gaaggctaga gggactgaac 2400 tatagcaagc aaggaaatgg agaggcagaa gatgaggtag gacacagaga ggaagtcagg 2460 agcctcatca tattagactc tgatggccat ggtaaaaaaa ttgaatttta ttttattttt 2520 atttattttt tgagacggag atttgttctt gttgcccagg ctggagtgca atggcgcgat 2580 ctcgactcac tgcaacctct gcctcctggg ttcaagtgat tctcctgcct cagcttccca 2640 agtagctggg attacaggtg cctgcgacca tactcggctt atttttttgt atttttagta 2700 gagacagggt atcaccatgt tggccaggct ggtctcaaac tcctgacctc agataatctg 2760 cctggcttcc caaagtgctg agattacagg cgtgagccac catgcccaac ctgaatttta 2820 tttgaataga tatgagaagc tactgtatgg ttacaaggac agtcaattta tattcgattt 2880 tttttttttg agacagagtc ttgctctgtt gcccaggcta gattgcagtg gtacaatctc 2940 agctcactgc aacctctgcc tcctgggttc cagcaattct cctgcctcag cctcccaagt 3000 agctgagacc acaggtacat gccactacac ctggctaatt ttttgtattt ttagtagaga 3060 tggggtttca ccgtgttagc caggatggtc ttgatctcct gacctcgtga tccactcccc 3120 tcggcctccc aaagtgctgg gattacaggt gtgagccacc acgcccggcc tatattcaat 3180 tattaaaatt aattctagct actctgtggg gattggattg ttgggtttca caagtggtca 3240 ggaagactat ttaggatcac agcagggaat tctccaggga aaacaggctt gtggcttcat 3300 agagtgcatt agtgataaag acagtgaaaa cgacaaagtg gacagactag gcatgtattt 3360 ttgcttagct tgttaatgga ttactctaaa gggggtagaa aaatcaagct tattcctaag 3420 gattttgttt tgacaaataa gtggatggtg gtgtttattg agataggaaa aactgtggga 3480 ggaaatgatt tgaagtgggt ggttggaaat aaaagttttg tttaaatttg agatgattta 3540 ttgacattta tgtggagcaa tccgaaggtc aatggcattt aagagactca tggtgaggtg 3600 aggccagggc ttcaggtatt tatgttggcg gcatcagtac gtgtaatgtg ttaaattcca 3660 gggagtggaa gaggatacat agggagatgg attgtgtgga gaaaaaagaa gagggtacag 3720 gccagcaaag ggggctgaga cagagcccag ggatgctgga gaaaacccaa gagaacataa 3780 tgggtgtaag tcatggaaaa tagattattt tcaaggagaa gggagaggtc aattgtggtg 3840 agtaccacta agaggagggg gaagtgagaa cgtgacagag aagcaagtgc tgggtttgct 3900 ggagttgata tttgcagtca atggagtatc cagggaggaa actggattgg accatttgaa 3960 gagcaagtag aagtgaggac gaggttaagg gtgactattt taagtagaga gcttcaggga 4020 aggactgtgc tctgggttca gggagcctgc tggatctaaa ggaaaagggc tgaagaggct 4080 gaagagaagg aggaggacct gtgaaccaga gatactgagt tattattagc aaggaaatac 4140 tagagggtcc ctgtgtgcag tgctgactgc tcatgcaaaa ggtcacacag acaatatttc 4200 acacagccag tatttattag tgacatagaa tatgccagtt attactctag gtcatgagaa 4260 tagagtgata aataaaatga atctggtcgc catcggtata tgccatgtaa cattttgcag 4320 tgactgtgta ccaggcctat gaatttcagt atgcaatttc aataacgatc ctgttgtatc 4380 tgtggtgttt aaaaacatat acatctctgg aatctaaaat tgagaggata taagtaaaac 4440 ccagtattag aaatttagtg ctggaaatca gactgcagtt taaatctgag catatagaaa 4500 gtccctttct tctatgtcag cagatgcctt ttgtgtgagg tttaggtata ctacattatt 4560 agacataaac cagtgattct gccctatgtt ttcagaatga caattcttta tgaaactaat 4620 agaagaacag aagacaattg caaaatcatg atgaagatgc tagtggcttt agaaccaagg 4680 aatacaaaaa ataatgtgag ctgcagttat agggattata aaagttaaaa tgggaatgca 4740 tttgagtgtt tattatgtga tcagtgctaa taagagtcat catttaattt tacacttaac 4800 aataatcctg tgaggattaa gctattatta aatgcatttg atagattaca aaaaggctta 4860 ccgttggtaa aaattgaccc aaggggaaga ggtcacattt ttattcagat tttctgattc 4920 tagagtttga gagtctgtcc atcattagtg agtagtgaca atactgtgtc taaattatcg 4980 acagaatttc tgatattcat atgtactatg ttgtttctta gagtgtgggc agagattcag 5040 ggctgctagt tccaatgtat aggagaaact ttcattcatt gtgcatttat cattttaaaa 5100 gttctaggct gggtgcggtg gctcatgcct gtaatcccag cactttggga ggccaaggcg 5160 ggcagatcac gaggtcagga gatgaagacc atcctggcta acatggtgaa acctcgtctc 5220 tactaaaaat acaaaaaatt agctgggcgt ggtggtgtgc acctgtagtc ccagctactt 5280 gggaggctga ggcaggagaa tggcatgaac ctgggaggcg gagcttgcag tgagctgaga 5340 tcgtgccact gcactccagc tccaccctgg gcaaaagagc gaaactccgt ctcaaaaaaa 5400 aaaaaaagtt ctatatgtct gtcatggcat atgttgaaga acacaaggaa gtattaaatc 5460 actccttctg aggtttgtct agcaagttgg gctaggattg ccaaataaaa tacaggtttc 5520 tagttaaatc tgaatttcag atacacaact ataatttact gaaaatccaa atgtaacttg 5580 gcatcctctg attttatttg ccaaatctgt caaccctaca tgagacacat gagcatggat 5640 tacggtgtta cccatggaag ccacagccac agtgacagcg acttcacaca tgtttatttt 5700 ttaactttct ctctgtaaag aaagtgctta gataatttag ggataaaaag atagacattg 5760 tttgatccag gatgcactcc tctctgccat cgtttctaaa gggcaaagag agatttccac 5820 aggtcttact cacagtctga ctcacagtct ggggacctgc tcatgctttg aaactgtctg 5880 tatgagaatg tcattttctt ggtttctccc tttctgaggg gacttgacta caaaactgag 5940 agttctacct ctggccaagg ctggaaattt gatgcctgct agtattgttg ggaatgggag 6000 actgaaataa atgagttagt tggggcatta aacaggaata aaatagctgt ggttgtgatt 6060 cattactaca attagtggac tagtggcaga gaaattaaga aagaagatga tgtgagagat 6120 aaattatatg atttggtaag gcaagggaat cagtaaatct tggttctgaa caagttcatt 6180 ttctggaaag atagcactgt actgggacca gaattctaca aaacatccgt tttatgtaag 6240 accaagattt tcaacaaata tttttcaatg cagttctcag ctgctccata actaatagtg 6300 acttattcaa cacagatatt ttcagatggt tcacacccat gtttcttacc cagggacagt 6360 tcaccacccc tccccttccc tcccatcact cttgaggaac atgtggcaat gttagaataa 6420 tttttggttg tcacaacagg ggtttcttct gatatttaat gagcagaagc cagggacact 6480 gctagagaac ccacaatgtt cagaatagac tccatcacca accaagattt atctcgtcca 6540 aaatgtcaat agtgctgagg ctggaagcat tggttcacac tgtgctcttt ctgaaaaatg 6600 tagactcgct tttttttttt ttttttttga gatggggtct tgctctgtcg cccagactgg 6660 agtgcagtgg ctccatctca gctcactaca acctctgcct cccaggttca agcgattctc 6720 ctgtctcagc ctccccagta gctgggatta caggtgcacc ctgccatgcc cggctaattt 6780 tttgtatttt agtagagatg gggtttcacc atgttgccca ggctggtctc gaactcctga 6840 gctcaggcaa tccacccgct ttggtctccc aaagtgctag gattacacgc atgagccacc 6900 gcgcccggcc tagactcaca tcttttatac acttactgcc caattcagtt ctttatggtt 6960 tatttttgct tgtttcatta taaaaaacta gacagttgca taaattcaac cacttacttg 7020 ttgaatccat ttagtcaatg caagctcaac attttcatat ttattttttg ccttatgcaa 7080 tattgttcaa cattttcata agttgttggt cagcactatc tctattaact ttcaacagtt 7140 tgcccttcta agtcacaaat agtgatgctg ctgcaattat ttttcactaa catgcctcag 7200 atttctgtag tgattctaca tttgatatta ttcacaatgt aaaatgcttc tatttattca 7260 tttcactttt acccacagga ttatttttaa gttatttttg tcattttcac acttcaacca 7320 aacataaaga caaaaacatc aaaaatatgt acatagtgtt atacataggt gtatatttac 7380 acacatatat gcacatatgt ttatatgtat tgaaactaca gaagcacatg tcaccaataa 7440 gagctctgag acacctttga ccacttaccc ttatcagatg agatttgcca aatgagtttt 7500 gggaacaaat ttcttttaac tgaatttctg agctttgtgg atttagaaat gcaactgaaa 7560 gtttgtggac atttacgagg atcatagttt tattctcctt aaaactcttc aatactttcc 7620 cattgtcttt agtaaatcca aaatcctaac accactcacg aggcttttca acacctggct 7680 tcttgtgatt tctccaatct aaccttttac cctccttccc ctcagcctct ctgctttagt 7740 gaactttgtt ctagtttttt gaagttcatc atcaattcaa gcttttgtac atgggatttc 7800 ctaaacctga aatgtgcctc cggttttgtc caaacagaca cacaggctcc actctgcccc 7860 ctggctcaca cctgcttaac ttgttaagtc acatctgtaa ctgtcactct tctctggcac 7920 cctaaaggaa ttgagatcat cctattattc tctgttctag aactccacac ttctgaaatt 7980 tctcattcct gtctaagctc ttgtgtgttt ggtttttggc catcactttc actgctctta 8040 aagctccccc agcggagtgg agaggtctgt tttcccgtgt ttggattcct agaggcagcg 8100 caggcctggc acaaggtcat cactaaggaa gtgttcacag gatgaaagcg gtgcgtgctg 8160 tttaaggaaa gggtaaagcc tttaaatggt aaagggttga gagaaggagc aaagtgcctt 8220 tggggtggag gctcccagga ggaggcggcg cgggctgcgg tgctggacgg atcctcctcc 8280 agctcctgcc tggaggtctc cagaacaggc tggaggcagg gagggggtcc caaaagcctt 8340 gggatcagag gtagtttttc cacctggtcc cccagacccc cgtccgcctc agaaagacag 8400 aggatgagcc cctgggctgc gtgttgtcgg ggttgcgggt ggggccagat agtgtcttcc 8460 ccggaggccg cttctgtaac cggatcgttc ttgtcccccc agcacgtttc ttggagcagg 8520 ttaaacatga gtgtcatttc ttcaacggga cggagcgggt gcggttcctg gacagatact 8580 tctatcacca agaggagtac gtgcgcttcg acagcgacgt gggggagtac cgggcggtga 8640 cggagctggg gcggcctgat gccgagtact ggaacagcca gaaggacctc ctggagcaga 8700 ggcgggccgc ggtggacacc tactgcagac acaactacgg ggttggtgag agcttcacag 8760 tgcagcggcg aggtgagcgc ggcgcggggc ggggcctgag tccctgtgag cggagaatct 8820 gagtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtga gagagagaga 8880 gagagagaga gagagagaga gcgccatctg tgagcattta gaatcctctc tatcctgagc 8940 aaggagttct gcgggcacag gtgtgtgtgt agagtgtgga tttgtccgtg tctgtgaggc 9000 tgttgtggga ggggaggcag gagggggctg cttcttattc ttggagactt ctgtggggag 9060 gtgacaaggg aggtgggtgc tgggggctgg agagagaggc gaccttgatt gtctcgggtc 9120 cttagagatg caaggaaggg aaatgtatgg ggtgtgtggt tggggtgaag gtttagggga 9180 ggagagctga ggggtaagga aggtttggga taatgtgaag aggccagttt cagactgtcc 9240 ctggcacaca cccttcatgt aatctctgaa ataaaagtgt gtgctgtttg tttgtaaaag 9300 cattagatta acttctaggg gaattgagta gacctctgag gcacctctga agcttcttta 9360 ggtataaatt tcttgctagt tttttgtttt cttagtgtta tatttttaca tagttgaaat 9420 gactgtgaaa ctaacttttt gaattaaagt ttgaaaacac tgttactatt ttattataat 9480 gctaataatt tcatagttac tttttaaata tataatagtt gtgacacaaa ttacctcact 9540 ttctttgttt ttttttttct tacactttaa gttttagggt acatgtgcac aacgtgcagg 9600 tttgttacat atgtatacat gtgccatgtt ggtgtgctgc acccattaac tcgtcattta 9660 acattaggta tatctcctaa tgctatccct ccccaccccc ccaccccaca acaggcccca 9720 gtgtgtgatg ttccccttcc tgtgtccatg tgttctcact gttcaattcc cacctatgag 9780 tgagaacatg cggtgttcgg ttttttgtcc ttgccatagt ttgctgagaa tgatggtttc 9840 cagcttcatc catgtcccta caaaggacat gaactcattc ttttttgtgg ctgcatagta 9900 ttccatagtg tatatgtgcc acattttctt aatccagtct atcattgttg gacatttggg 9960 ttggttccaa gtctttgcta ttgtgaatag tgccgcaata aacatacatg tgcatatgtc 10020 tttatagcag catgatttat aatccttggg ttatataccc agtaatggga tggctgggtc 10080 aaatggtatt tctagttcta gatccctgag gaatcgccac actgacttcc acaatggttg 10140 aactagttta gagtcccacc aacagggtaa aagtgttcct atttctccac atcctctcca 10200 gcacctgttg cttcctgact ttttaatgat cgccattcta actggtgtga gatggtatct 10260 cattgtggtt ttgatttgca attctctgat ggccagtgat gatgagcatt ttttcatgtg 10320 tcttttggct gcataaatgt cttcttttga gaagtgtctg ttcatgtcct ttgcccactt 10380 tttgatgggg tattttgttt ttttcttgta aatttgtttg agttcattgc agattctgga 10440 tattagccct ttgtcatatg agtagattgc aaaaattttc tcccattctg taggttgcct 10500 cttcactctg atggtagttt cttttgctgt gcagaagctc tttagtttaa ttagatccca 10560 tttgtccatt ttggcttttg ttgccattgc ttttggtgtt ttagacatga agttcttgcc 10620 catgcctatg tcctgaatgg tattgcctag gttttcttct agggttttta tggtttcagg 10680 tctaacattt aagtctttaa tccatcttga attaattttt gtataagcaa attacgtcac 10740 tttccccatt gatgaccttt attatgacat tcaccaatag ttgaaaatgt atgtttctgg 10800 ttaatttttg atttatattt ttttgatttg taattatttt gaattatttt gacctattta 10860 ttggccagtt gtaattactg ctctgctcta cgaattacct gttgtatttg gtaggtaatg 10920 gacaatgatc tattgtctct tatctttagg gcttagtatt tttctcagtg actttgtggg 10980 tttgttgtac tgtaagatta ttaacacttt attgatattt gattcagtat tttctccagt 11040 ttgtggtatg tatattttga aaattctttt ccatgttaag aatttgaaca tttttattta 11100 ataaaatata ttgcaaaatg ttaattaatg attcacaaac tagctcaagt ctaccatttt 11160 gtggtattga tgtctccagg tttctccttc cttcttaaaa aaaaatgtat ttattgagag 11220 tatgctagtg tcagggattt ccctaggcat aagcactcca agtaatgagt cccagacact 11280 gccttgatcc aaatgtcatt ctggaaagaa aaatcatttt acagtgataa gcctaataat 11340 agttatactt gttttgcctg ggagatgcat tgatcagcta aatgtaaata taagaacttt 11400 caaaactaaa atgacgttcc ttaatctttc tctctgcttt aggaatcatg ctttcttagg 11460 aacttaaaga tttggagaat catttctgtc tgtcccacct tcccaggagc ataaccattt 11520 ctgtggtgtt ctaaggtgtg agtgcatggc agtagtattc ctaaaaatcc atattcagtt 11580 tcctcatgtg ccctactccg tccctttctc tatccacatt gctttaaatc atatttttct 11640 ctcaaggtgt acaaggatga taaataggtg ccaagtggag aacccaagtg tgacgagccc 11700 tctcacagta gaatggagtg agaagctttc tgacctcata aattgaaggc tatcgtaatt 11760 cattctttta tatattttac ttgcattaat cctcatataa cctcaagagg taaattaata 11820 taattatcct ccattattgg agagaaagtt gagacacaaa agaatcaaaa actcttccag 11880 gatcaaccag taaaaggcag accttggatt tgaaccaggc aacctggctc agaagtcagt 11940 tttaattacc acactctgta ctttcaaaga tttgtaaacg ctttgacaat gcatgtcaat 12000 ttcaagctat gaagagccaa acataatttt tcacaatatc tctcaaatct aatgggtccc 12060 cactataaag attaaattcc aggctgatga cactgtgagg ccacatggcc agctgtgctg 12120 gaggcctgct caaggccaga gcctaggttt acagagaagc agacaaaaag ctaaacaagg 12180 agacttactc tgtctgcatg acttattccc tctaccttgt tttctcctag tctatcctga 12240 ggtgactgtg tatcctgcaa agacccagcc cctgcagcac cacaacctcc tggtctgctc 12300 tgtgaatggt ttctatccag gcagcattga agtcaggtgg ttccggaacg gccaggaaga 12360 gaagactggg gtggtgtcca caggcctgat ccagaatgga gactggacct tccagaccct 12420 ggtgatgctg gaaacagttc ctcggagtgg agaggtttac acctgccaag tggagcaccc 12480 aagcctgacg agccctctca cagtggaatg gagtgagcag ctttctgact tcataaattt 12540 ctcacccacc aagacgcgaa ctttactaat ccctgagtat caggcttctc ctatcccaca 12600 tcctattttc atttgctcca cgttctcatc tccatcagca caggtcactg gggggtagcc 12660 ctgtaatact ttctagaaac acctgtaccc cctggggaag cagtcatgcc tgccaggcag 12720 gagaggctgt ccctcttttg aacctcccca tgatgtcaca agtcggggtc acctgctgtc 12780 tgtgggctcc aggccctgcc tctgggtctg agactgagtt tctggtactg ttgctctgag 12840 tcgtttgttg taatctgaga agaggagaag tatagggacc ttcctgacat gaggggagtc 12900 caatctcagc tccgcctttt attagatctg tcactctagg caactactta acctcattgg 12960 gtctcaggct ttctgttcat cagatgttga agtcctgtct tacatcaagg ctgtaatatt 13020 tgaatgagtt tgatgactga accttgtaac tgttcagtgt gatttgaaaa cctttctcaa 13080 gaaatggtca gttattttag ttcttgcaga gcagccttct ttctcatttt caaagctctg 13140 aatctcaagg tgtcaattaa agaggttcca tttgggataa aaatcactaa acctggcttc 13200 ctctctcagg agcacggtct gaatctgcac agagcaagat gctgagtgga gtcgggggct 13260 tcgtgctggg cctgctcttc cttggggccg ggctgttcat ctacttcagg aatcagaaag 13320 gtgaggagcc tttggtagct ggctgtctcc atacgctttt ctggaggagg aactatggct 13380 ttgctgaagt tggttctcag catatgaatg gccctggata aagcctctct actcccaaat 13440 gacctccaat gttctgcaaa tccagaaatc atcagtgcat ggttgctatg tcaaagcata 13500 atagcttgtg gcctacagag ataacagaaa gattaacagg tataggtgct ttggttgaga 13560 tcgtggagca aattaaggaa gagcaactaa agctaataca attacactgg atcctgtgac 13620 agacacttca cacttcatgg gtcacatggt ctgtttctgc tcctctctgc cctggctggt 13680 gtgggttgtg gtgtcagaga actctcaggt gggagatctg gagctgggac attgtgttgg 13740 aggacagatt tgcttccata tcctttaagt gtatatcttc tctttttcct aggacactct 13800 ggacttcagc caacaggtaa taccttttca tcctctttaa gaaacagatt tggaggccag 13860 gcgcagtggc tcacgcctgt aatcccagca ctttgggagg ccgaggcggg cgaatcatga 13920 ggtcaggagt tcgagaccag cctgaccaac gtggtgaaac cccgtctcta ctaaaaatac 13980 aaaaaaaaat cagtcgggcg tggtggtgtg cgcctgtaat cccagctact caggaggcca 14040 aggcaggaga atcgctggaa cccaggaggc agaggttgca gtgagccgag attgggccac 14100 tgcactccag cctaggtgac agagtgagac cccatctcaa aaaaacaaaa aaaagaaaga 14160 aagaaacaga tttcctttcc ctagaatgat ggtagaggta ataaggcatg agacagaagt 14220 aatagcaaag acattggatc caaatttctg atcaggcaat ttacaccaga actcctcctc 14280 tccacttaga aaaggcctgt gctctgcagg agtattgact catggagact tcagaacttg 14340 tttttcttct tcctgcagtg ctctcatctg agtccttgaa agagggcaaa ataaactgtt 14400 agtagagcca ggtctgaaaa caacactttc ttgcgtctct gcaggattcc tgagctgaag 14460 tgaagatgac cacattcaag gaagaacctt ctgc 14494 // ID OV305418; SV 1; linear; genomic DNA; STD; HUM; 14494 BP. XX AC OV305418; XX PR Project:PRJEB49636; XX DT 06-JAN-2022 (Rel. 144, Created) DT 06-JAN-2022 (Rel. 144, Last updated, Version 1) XX DE Homo sapiens HLA-DRB1 gene for MHC class II antigen, allele DE HLA-DRB1*04:08:01 XX KW . XX OS Homo sapiens (human) OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. XX RN [1] RA Lucas J., Lucas AM J.; RT ; RL Submitted (21-DEC-2021) to the INSDC. RL ANTHONY NOLAN RESEARCH INSTITUTE, 77C Fleet Road, London, NW3 2QU, United RL Kingdom XX DR MD5; 7db717d66a285bce7228b759d130bd94. XX FH Key Location/Qualifiers FH FT source 1..14494 FT /organism="Homo sapiens" FT /mol_type="genomic DNA" FT /clone="AN300797" FT /db_xref="taxon:9606" FT CDS join(146..245,8503..8772,12231..12512,13210..13320, FT 13793..13816,14445..14458) FT /codon_start=1 FT /transl_table=1 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /product="MHC class II antigen" FT /function="antigen presenting molecule" FT /protein_id="CAH1028210.1" FT /translation="MVCLKFPGGSCMAALTVTLMVLSSPLALAGDTRPRFLEQVKHECH FT FFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRAAV FT DTYCRHNYGVGESFTVQRRVYPEVTVYPAKTQPLQHHNLLVCSVNGFYPGSIEVRWFRN FT GQEEKTGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSLTSPLTVEWRARSE FT SAQSKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS" FT exon 146..245 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=1 FT intron 246..8502 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=1 FT exon 8503..8772 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=2 FT intron 8773..12230 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=2 FT exon 12231..12512 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=3 FT intron 12513..13209 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=3 FT exon 13210..13320 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=4 FT intron 13321..13792 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=4 FT exon 13793..13816 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=5 FT intron 13817..14444 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=5 FT exon 14445..14458 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=6 XX SQ Sequence 14494 BP; 3869 A; 2932 C; 3282 G; 4411 T; 0 other; tccaacacta gattacccaa tccacgagca aggaaatcag taacttcttc cctataattt 60 ggaatgtggg tggagagggg tcatagttct ccctgagtga gactcacctg ctcctctggc 120 ccctggtcct gtcctgttct ccagcatggt gtgtctgaag ttccctggag gctcctgcat 180 ggcagctctg acagtgacac tgatggtgct gagctcccca ctggctttgg ctggggacac 240 ccgacgtaag tgcacattgt gggtgctgac ctactatggg gtggggaaaa aagggagttg 300 tgttaacatt gtgcccaggc catgtccctt aagaaagtgt gacattttct tcagggattg 360 cccatcttta tcatatggat cccaaattat ttccaccaca aatggaactt ggctacttgc 420 cctattcatg agactgtgta aagggccttt gtacaggcca tgttttactt taaatctcta 480 ccaataaaac ctttgcatca catgtcctca gggtctttag aggatttaga aataaggatg 540 ctaaaataaa ttcctcatac agcacttccc tttatcatgt tgacttatgt cagacgaaac 600 aaggttttgt tttgaaaatt ttgtgggagt caaaggaatt caaagggtct ctcctagacg 660 atcctgtgtt gtcctccaca ggacctgtgg tgttggcccc tcttcctcat atgtgaggat 720 gtacccagtg gcctccccat tgtttccttt cttttttttc tgaactccag tgtttataaa 780 gcctgtatcc ctgtagcata tgtaggttct ctgacagaag ttatacttag tgctctttct 840 ttcttatggg gaaaaatccc tggatctgaa actgacatct ttagtacttg gagtcaccct 900 acaggtaaag accatttatg aggtattcat tggtgcctcc tcttgatcgg tctctcagac 960 ccctgaatac ttggatactc ctcaagaact taaggcatcc tctgaaaaac tggcccagat 1020 tagtgcttat tattaatctt ttataacctt tctatacttg tttctcctgc atgctctaac 1080 tagacatgac agaagagatt caactaacat aggataaatt atatgaaatt ctatttttgt 1140 aagtcaaaaa tagtcaaata ccagaaaatt aataatgttc aaactatata ctctgtgtgg 1200 ggttaccgag acgacgtgga cattgttcac atctaatagg gctgaaagtc aatgaagaag 1260 tcctggaaac tccttgtctt actggggtct tgtcctaaat ttcataggtt cacccatcat 1320 gccctcagct ttccttaatt agccatgtct gcttatctct acctccagtt tctctctatt 1380 tttccccagc tatgttgtca tcatttccag aaatctctaa aacttgcaaa gatccttagc 1440 actatgagat ccattgaaag agataatttt tttctttttg agacagggct tggttctgtc 1500 acccaggctg tagtgcagtg gtgtgatcta ggctcactgc aacctctgct tcccacgctc 1560 aagtgatcct ccctcctcag cctccagagt agcggagact acaggcaggc aaacatgtgc 1620 agctaatttt catgattttg ttagagatga gattttgcca tgttgcccag gctgttctta 1680 aactcctgga ctcaagcaat cctcctgcct tagcctccca atatgctagg attatagatg 1740 tgagccattg tgcccaggca aaaagagatg aaccttaatt taaaaatttc ctttttctta 1800 aatcactgtt tctctatctg tgaattcttc ttccaactag aaggaggaga aagaagaagt 1860 ttgcctgtat ttctcaccag gaggaggagt ctagtgtgat atcaaaatga aagagtgctg 1920 gagcttgatc cccttcttgc tttccaggat ccctgcagtg atcagttccc acaccctggt 1980 ttattcatgt aaagcacact tatttttttc agcagctact ctttactggg ctccattcta 2040 agttcaaatc attctatttg agtaagatag agagggtccc gactctcatg gaagttacac 2100 aagagtagag gagacagaca ctaacccaat aagcatttaa caaagaagaa aatgttagag 2160 agacatagtg cactgaagaa aagacatcag gtttgtgaaa aagagagaca tggattcact 2220 tactttggtt catatgctta ggcagctata actgagaaag tgacattcag ctgagacaac 2280 aaaataaata gacagtcgtg aagatctaaa ggacgaaagt tccagggaga atgaatgggg 2340 gggaagctct ggtgtgggaa attatgtgga aggacagaaa gaaggctaga gggactgaac 2400 tatagcaagc aaggaaatgg agaggcagaa gatgaggtag gacacagaga ggaagtcagg 2460 agcctcatca tattagactc tgatggccat ggtaaaaaaa ttgaatttta ttttattttt 2520 atttattttt tgagacggag atttgttctt gttgcccagg ctggagtgca atggcgcgat 2580 ctcgactcac tgcaacctct gcctcctggg ttcaagtgat tctcctgcct cagcttccca 2640 agtagctggg attacaggtg cctgcgacca tactcggctt atttttttgt atttttagta 2700 gagacagggt atcaccatgt tggccaggct ggtctcaaac tcctgacctc agataatctg 2760 cctggcttcc caaagtgctg agattacagg cgtgagccac catgcccaac ctgaatttta 2820 tttgaataga tatgagaagc tactgtatgg ttacaaggac agtcaattta tattcgattt 2880 tttttttttg agacagagtc ttgctctgtt gcccaggcta gattgcagtg gtacaatctc 2940 agctcactgc aacctctgcc tcctgggttc cagcaattct cctgcctcag cctcccaagt 3000 agctgagacc acaggtacat gccactacac ctggctaatt ttttgtattt ttagtagaga 3060 tggggtttca ccgtgttagc caggatggtc ttgatctcct gacctcgtga tccactcccc 3120 tcggcctccc aaagtgctgg gattacaggt gtgagccacc acgcccggcc tatattcaat 3180 tattaaaatt aattctagct actctgtggg gattggattg ttgggtttca caagtggtca 3240 ggaagactat ttaggatcac agcagggaat tctccaggga aaacaggctt gtggcttcat 3300 agagtgcatt agtgataaag acagtgaaaa cgacaaagtg gacagactag gcatgtattt 3360 ttgcttagct tgttaatgga ttactctaaa gggggtagaa aaatcaagct tattcctaag 3420 gattttgttt tgacaaataa gtggatggtg gtgtttattg agataggaaa aactgtggga 3480 ggaaatgatt tgaagtgggt ggttggaaat aaaagttttg tttaaatttg agatgattta 3540 ttgacattta tgtggagcaa tccgaaggtc aatggcattt aagagactca tggtgaggtg 3600 aggccagggc ttcaggtatt tatgttggcg gcatcagtac gtgtaatgtg ttaaattcca 3660 gggagtggaa gaggatacat agggagatgg attgtgtgga gaaaaaagaa gagggtacag 3720 gccagcaaag ggggctgaga cagagcccag ggatgctgga gaaaacccaa gagaacataa 3780 tgggtgtaag tcatggaaaa tagattattt tcaaggagaa gggagaggtc aattgtggtg 3840 agtaccacta agaggagggg gaagtgagaa cgtgacagag aagcaagtgc tgggtttgct 3900 ggagttgata tttgcagtca atggagtatc cagggaggaa actggattgg accatttgaa 3960 gagcaagtag aagtgaggac gaggttaagg gtgactattt taagtagaga gcttcaggga 4020 aggactgtgc tctgggttca gggagcctgc tggatctaaa ggaaaagggc tgaagaggct 4080 gaagagaagg aggaggacct gtgaaccaga gatactgagt tattattagc aaggaaatac 4140 tagagggtcc ctgtgtgcag tgctgactgc tcatgcaaaa ggtcacacag acaatatttc 4200 acacagccag tatttattag tgacatagaa tatgccagtt attactctag gtcatgagaa 4260 tagagtgata aataaaatga atctggtcgc catcggtata tgccatgtaa cattttgcag 4320 tgactgtgta ccaggcctat gaatttcagt atgcaatttc aataacgatc ctgttgtatc 4380 tgtggtgttt aaaaacatat acatctctgg aatctaaaat tgagaggata taagtaaaac 4440 ccagtattag aaatttagtg ctggaaatca gactgcagtt taaatctgag catatagaaa 4500 gtccctttct tctatgtcag cagatgcctt ttgtgtgagg tttaggtata ctacattatt 4560 agacataaac cagtgattct gccctatgtt ttcagaatga caattcttta tgaaactaat 4620 agaagaacag aagacaattg caaaatcatg atgaagatgc tagtggcttt agaaccaagg 4680 aatacaaaaa ataatgtgag ctgcagttat agggattata aaagttaaaa tgggaatgca 4740 tttgagtgtt tattatgtga tcagtgctaa taagagtcat catttaattt tacacttaac 4800 aataatcctg tgaggattaa gctattatta aatgcatttg atagattaca aaaaggctta 4860 ccgttggtaa aaattgaccc aaggggaaga ggtcacattt ttattcagat tttctgattc 4920 tagagtttga gagtctgtcc atcattagtg agtagtgaca atactgtgtc taaattatcg 4980 acagaatttc tgatattcat atgtactatg ttgtttctta gagtgtgggc agagattcag 5040 ggctgctagt tccaatgtat aggagaaact ttcattcatt gtgcatttat cattttaaaa 5100 gttctaggct gggtgcggtg gctcatgcct gtaatcccag cactttggga ggccaaggcg 5160 ggcagatcac gaggtcagga gatgaagacc atcctggcta acatggtgaa acctcgtctc 5220 tactaaaaat acaaaaaatt agctgggcgt ggtggtgtgc acctgtagtc ccagctactt 5280 gggaggctga ggcaggagaa tggcatgaac ctgggaggcg gagcttgcag tgagctgaga 5340 tcgtgccact gcactccagc tccaccctgg gcaaaagagc gaaactccgt ctcaaaaaaa 5400 aaaaaaagtt ctatatgtct gtcatggcat atgttgaaga acacaaggaa gtattaaatc 5460 actccttctg aggtttgtct agcaagttgg gctaggattg ccaaataaaa tacaggtttc 5520 tagttaaatc tgaatttcag atacacaact ataatttact gaaaatccaa atgtaacttg 5580 gcatcctctg attttatttg ccaaatctgt caaccctaca tgagacacat gagcatggat 5640 tacggtgtta cccatggaag ccacagccac agtgacagcg acttcacaca tgtttatttt 5700 ttaactttct ctctgtaaag aaagtgctta gataatttag ggataaaaag atagacattg 5760 tttgatccag gatgcactcc tctctgccat cgtttctaaa gggcaaagag agatttccac 5820 aggtcttact cacagtctga ctcacagtct ggggacctgc tcatgctttg aaactgtctg 5880 tatgagaatg tcattttctt ggtttctccc tttctgaggg gacttgacta caaaactgag 5940 agttctacct ctggccaagg ctggaaattt gatgcctgct agtattgttg ggaatgggag 6000 actgaaataa atgagttagt tggggcatta aacaggaata aaatagctgt ggttgtgatt 6060 cattactaca attagtggac tagtggcaga gaaattaaga aagaagatga tgtgagagat 6120 aaattatatg atttggtaag gcaagggaat cagtaaatct tggttctgaa caagttcatt 6180 ttctggaaag atagcactgt actgggacca gaattctaca aaacatccgt tttatgtaag 6240 accaagattt tcaacaaata tttttcaatg cagttctcag ctgctccata actaatagtg 6300 acttattcaa cacagatatt ttcagatggt tcacacccat gtttcttacc cagggacagt 6360 tcaccacccc tccccttccc tcccatcact cttgaggaac atgtggcaat gttagaataa 6420 tttttggttg tcacaacagg ggtttcttct gatatttaat gagcagaagc cagggacact 6480 gctagagaac ccacaatgtt cagaatagac tccatcacca accaagattt atctcgtcca 6540 aaatgtcaat agtgctgagg ctggaagcat tggttcacac tgtgctcttt ctgaaaaatg 6600 tagactcgct tttttttttt ttttttttga gatggggtct tgctctgtcg cccagactgg 6660 agtgcagtgg ctccatctca gctcactaca acctctgcct cccaggttca agcgattctc 6720 ctgtctcagc ctccccagta gctgggatta caggtgcacc ctgccatgcc cggctaattt 6780 tttgtatttt agtagagatg gggtttcacc atgttgccca ggctggtctc gaactcctga 6840 gctcaggcaa tccacccgct ttggtctccc aaagtgctag gattacacgc atgagccacc 6900 gcgcccggcc tagactcaca tcttttatac acttactgcc caattcagtt ctttatggtt 6960 tatttttgct tgtttcatta taaaaaacta gacagttgca taaattcaac cacttacttg 7020 ttgaatccat ttagtcaatg caagctcaac attttcatat ttattttttg ccttatgcaa 7080 tattgttcaa cattttcata agttgttggt cagcactatc tctattaact ttcaacagtt 7140 tgcccttcta agtcacaaat agtgatgctg ctgcaattat ttttcactaa catgcctcag 7200 atttctgtag tgattctaca tttgatatta ttcacaatgt aaaatgcttc tatttattca 7260 tttcactttt acccacagga ttatttttaa gttatttttg tcattttcac acttcaacca 7320 aacataaaga caaaaacatc aaaaatatgt acatagtgtt atacataggt gtatatttac 7380 acacatatat gcacatatgt ttatatgtat tgaaactaca gaagcacatg tcaccaataa 7440 gagctctgag acacctttga ccacttaccc ttatcagatg agatttgcca aatgagtttt 7500 gggaacaaat ttcttttaac tgaatttctg agctttgtgg atttagaaat gcaactgaaa 7560 gtttgtggac atttacgagg atcatagttt tattctcctt aaaactcttc aatactttcc 7620 cattgtcttt agtaaatcca aaatcctaac accactcacg aggcttttca acacctggct 7680 tcttgtgatt tctccaatct aaccttttac cctccttccc ctcagcctct ctgctttagt 7740 gaactttgtt ctagtttttt gaagttcatc atcaattcaa gcttttgtac atgggatttc 7800 ctaaacctga aatgtgcctc cggttttgtc caaacagaca cacaggctcc actctgcccc 7860 ctggctcaca cctgcttaac ttgttaagtc acatctgtaa ctgtcactct tctctggcac 7920 cctaaaggaa ttgagatcat cctattattc tctgttctag aactccacac ttctgaaatt 7980 tctcattcct gtctaagctc ttgtgtgttt ggtttttggc catcactttc actgctctta 8040 aagctccccc agcggagtgg agaggtctgt tttcccgtgt ttggattcct agaggcagcg 8100 caggcctggc acaaggtcat cactaaggaa gtgttcacag gatgaaagcg gtgcgtgctg 8160 tttaaggaaa gggtaaagcc tttaaatggt aaagggttga gagaaggagc aaagtgcctt 8220 tggggtggag gctcccagga ggaggcggcg cgggctgcgg tgctggacgg atcctcctcc 8280 agctcctgcc tggaggtctc cagaacaggc tggaggcagg gagggggtcc caaaagcctt 8340 gggatcagag gtagtttttc cacctggtcc cccagacccc cgtccgcctc agaaagacag 8400 aggatgagcc cctgggctgc gtgttgtcgg ggttgcgggt ggggccagat agtgtcttcc 8460 ccggaggccg cttctgtaac cggatcgttc ttgtcccccc agcacgtttc ttggagcagg 8520 ttaaacatga gtgtcatttc ttcaacggga cggagcgggt gcggttcctg gacagatact 8580 tctatcacca agaggagtac gtgcgcttcg acagcgacgt gggggagtac cgggcggtga 8640 cggagctggg gcggcctgat gccgagtact ggaacagcca gaaggacctc ctggagcaga 8700 ggcgggccgc ggtggacacc tactgcagac acaactacgg ggttggtgag agcttcacag 8760 tgcagcggcg aggtgagcgc ggcgcggggc ggggcctgag tccctgtgag cggagaatct 8820 gagtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtga gagagagaga 8880 gagagagaga gagagagaga gcgccatctg tgagcattta gaatcctctc tatcctgagc 8940 aaggagttct gcgggcacag gtgtgtgtgt agagtgtgga tttgtccgtg tctgtgaggc 9000 tgttgtggga ggggaggcag gagggggctg cttcttattc ttggagactt ctgtggggag 9060 gtgacaaggg aggtgggtgc tgggggctgg agagagaggc gaccttgatt gtctcgggtc 9120 cttagagatg caaggaaggg aaatgtatgg ggtgtgtggt tggggtgaag gtttagggga 9180 ggagagctga ggggtaagga aggtttggga taatgtgaag aggccagttt cagactgtcc 9240 ctggcacaca cccttcatgt aatctctgaa ataaaagtgt gtgctgtttg tttgtaaaag 9300 cattagatta acttctaggg gaattgagta gacctctgag gcacctctga agcttcttta 9360 ggtataaatt tcttgctagt tttttgtttt cttagtgtta tatttttaca tagttgaaat 9420 gactgtgaaa ctaacttttt gaattaaagt ttgaaaacac tgttactatt ttattataat 9480 gctaataatt tcatagttac tttttaaata tataatagtt gtgacacaaa ttacctcact 9540 ttctttgttt ttttttttct tacactttaa gttttagggt acatgtgcac aacgtgcagg 9600 tttgttacat atgtatacat gtgccatgtt ggtgtgctgc acccattaac tcgtcattta 9660 acattaggta tatctcctaa tgctatccct ccccaccccc ccaccccaca acaggcccca 9720 gtgtgtgatg ttccccttcc tgtgtccatg tgttctcact gttcaattcc cacctatgag 9780 tgagaacatg cggtgttcgg ttttttgtcc ttgccatagt ttgctgagaa tgatggtttc 9840 cagcttcatc catgtcccta caaaggacat gaactcattc ttttttgtgg ctgcatagta 9900 ttccatagtg tatatgtgcc acattttctt aatccagtct atcattgttg gacatttggg 9960 ttggttccaa gtctttgcta ttgtgaatag tgccgcaata aacatacatg tgcatatgtc 10020 tttatagcag catgatttat aatccttggg ttatataccc agtaatggga tggctgggtc 10080 aaatggtatt tctagttcta gatccctgag gaatcgccac actgacttcc acaatggttg 10140 aactagttta gagtcccacc aacagggtaa aagtgttcct atttctccac atcctctcca 10200 gcacctgttg cttcctgact ttttaatgat cgccattcta actggtgtga gatggtatct 10260 cattgtggtt ttgatttgca attctctgat ggccagtgat gatgagcatt ttttcatgtg 10320 tcttttggct gcataaatgt cttcttttga gaagtgtctg ttcatgtcct ttgcccactt 10380 tttgatgggg tattttgttt ttttcttgta aatttgtttg agttcattgc agattctgga 10440 tattagccct ttgtcatatg agtagattgc aaaaattttc tcccattctg taggttgcct 10500 cttcactctg atggtagttt cttttgctgt gcagaagctc tttagtttaa ttagatccca 10560 tttgtccatt ttggcttttg ttgccattgc ttttggtgtt ttagacatga agttcttgcc 10620 catgcctatg tcctgaatgg tattgcctag gttttcttct agggttttta tggtttcagg 10680 tctaacattt aagtctttaa tccatcttga attaattttt gtataagcaa attacgtcac 10740 tttccccatt gatgaccttt attatgacat tcaccaatag ttgaaaatgt atgtttctgg 10800 ttaatttttg atttatattt ttttgatttg taattatttt gaattatttt gacctattta 10860 ttggccagtt gtaattactg ctctgctcta cgaattacct gttgtatttg gtaggtaatg 10920 gacaatgatc tattgtctct tatctttagg gcttagtatt tttctcagtg actttgtggg 10980 tttgttgtac tgtaagatta ttaacacttt attgatattt gattcagtat tttctccagt 11040 ttgtggtatg tatattttga aaattctttt ccatgttaag aatttgaaca tttttattta 11100 ataaaatata ttgcaaaatg ttaattaatg attcacaaac tagctcaagt ctaccatttt 11160 gtggtattga tgtctccagg tttctccttc cttcttaaaa aaaaatgtat ttattgagag 11220 tatgctagtg tcagggattt ccctaggcat aagcactcca agtaatgagt cccagacact 11280 gccttgatcc aaatgtcatt ctggaaagaa aaatcatttt acagtgataa gcctaataat 11340 agttatactt gttttgcctg ggagatgcat tgatcagcta aatgtaaata taagaacttt 11400 caaaactaaa atgacgttcc ttaatctttc tctctgcttt aggaatcatg ctttcttagg 11460 aacttaaaga tttggagaat catttctgtc tgtcccacct tcccaggagc ataaccattt 11520 ctgtggtgtt ctaaggtgtg agtgcatggc agtagtattc ctaaaaatcc atattcagtt 11580 tcctcatgtg ccctactccg tccctttctc tatccacatt gctttaaatc atatttttct 11640 ctcaaggtgt acaaggatga taaataggtg ccaagtggag aacccaagtg tgacgagccc 11700 tctcacagta gaatggagtg agaagctttc tgacctcata aattgaaggc tatcgtaatt 11760 cattctttta tatattttac ttgcattaat cctcatataa cctcaagagg taaattaata 11820 taattatcct ccattattgg agagaaagtt gagacacaaa agaatcaaaa actcttccag 11880 gatcaaccag taaaaggcag accttggatt tgaaccaggc aacctggctc agaagtcagt 11940 tttaattacc acactctgta ctttcaaaga tttgtaaacg ctttgacaat gcatgtcaat 12000 ttcaagctat gaagagccaa acataatttt tcacaatatc tctcaaatct aatgggtccc 12060 cactataaag attaaattcc aggctgatga cactgtgagg ccacatggcc agctgtgctg 12120 gaggcctgct caaggccaga gcctaggttt acagagaagc agacaaaaag ctaaacaagg 12180 agacttactc tgtctgcatg acttattccc tctaccttgt tttctcctag tctatcctga 12240 ggtgactgtg tatcctgcaa agacccagcc cctgcagcac cacaacctcc tggtctgctc 12300 tgtgaatggt ttctatccag gcagcattga agtcaggtgg ttccggaacg gccaggaaga 12360 gaagactggg gtggtgtcca caggcctgat ccagaatgga gactggacct tccagaccct 12420 ggtgatgctg gaaacagttc ctcggagtgg agaggtttac acctgccaag tggagcaccc 12480 aagcctgacg agccctctca cagtggaatg gagtgagcag ctttctgact tcataaattt 12540 ctcacccacc aagacgcgaa ctttactaat ccctgagtat caggcttctc ctatcccaca 12600 tcctattttc atttgctcca cgttctcatc tccatcagca caggtcactg gggggtagcc 12660 ctgtaatact ttctagaaac acctgtaccc cctggggaag cagtcatgcc tgccaggcag 12720 gagaggctgt ccctcttttg aacctcccca tgatgtcaca agtcggggtc acctgctgtc 12780 tgtgggctcc aggccctgcc tctgggtctg agactgagtt tctggtactg ttgctctgag 12840 tcgtttgttg taatctgaga agaggagaag tatagggacc ttcctgacat gaggggagtc 12900 caatctcagc tccgcctttt attagatctg tcactctagg caactactta acctcattgg 12960 gtctcaggct ttctgttcat cagatgttga agtcctgtct tacatcaagg ctgtaatatt 13020 tgaatgagtt tgatgactga accttgtaac tgttcagtgt gatttgaaaa cctttctcaa 13080 gaaatggtca gttattttag ttcttgcaga gcagccttct ttctcatttt caaagctctg 13140 aatctcaagg tgtcaattaa agaggttcca tttgggataa aaatcactaa acctggcttc 13200 ctctctcagg agcacggtct gaatctgcac agagcaagat gctgagtgga gtcgggggct 13260 tcgtgctggg cctgctcttc cttggggccg ggctgttcat ctacttcagg aatcagaaag 13320 gtgaggagcc tttggtagct ggctgtctcc atacgctttt ctggaggagg aactatggct 13380 ttgctgaagt tggttctcag catatgaatg gccctggata aagcctctct actcccaaat 13440 gacctccaat gttctgcaaa tccagaaatc atcagtgcat ggttgctatg tcaaagcata 13500 atagcttgtg gcctacagag ataacagaaa gattaacagg tataggtgct ttggttgaga 13560 tcgtggagca aattaaggaa gagcaactaa agctaataca attacactgg atcctgtgac 13620 agacacttca cacttcatgg gtcacatggt ctgtttctgc tcctctctgc cctggctggt 13680 gtgggttgtg gtgtcagaga actctcaggt gggagatctg gagctgggac attgtgttgg 13740 aggacagatt tgcttccata tcctttaagt gtatatcttc tctttttcct aggacactct 13800 ggacttcagc caacaggtaa taccttttca tcctctttaa gaaacagatt tggaggccag 13860 gcgcagtggc tcacgcctgt aatcccagca ctttgggagg ccgaggcggg cgaatcatga 13920 ggtcaggagt tcgagaccag cctgaccaac gtggtgaaac cccgtctcta ctaaaaatac 13980 aaaaaaaaat cagtcgggcg tggtggtgtg cgcctgtaat cccagctact caggaggcca 14040 aggcaggaga atcgctggaa cccaggaggc agaggttgca gtgagccgag attgggccac 14100 tgcactccag cctaggtgac agagtgagac cccatctcaa aaaaacaaaa aaaagaaaga 14160 aagaaacaga tttcctttcc ctagaatgat ggtagaggta ataaggcatg agacagaagt 14220 aatagcaaag acattggatc caaatttctg atcaggcaat ttacaccaga actcctcctc 14280 tccacttaga aaaggcctgt gctctgcagg agtattgact catggagact tcagaacttg 14340 tttttcttct tcctgcagtg ctctcatctg agtccttgaa agagggcaaa ataaactgtt 14400 agtagagcca ggtctgaaaa caacactttc ttgcgtctct gcaggattcc tgagctgaag 14460 tgaagatgac cacattcaag gaagaacctt ctgc 14494 // ID OV305434; SV 1; linear; genomic DNA; STD; HUM; 14494 BP. XX AC OV305434; XX PR Project:PRJEB49636; XX DT 06-JAN-2022 (Rel. 144, Created) DT 06-JAN-2022 (Rel. 144, Last updated, Version 1) XX DE Homo sapiens HLA-DRB1 gene for MHC class II antigen, allele DE HLA-DRB1*04:08:01 XX KW . XX OS Homo sapiens (human) OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. XX RN [1] RA Lucas J., Lucas AM J.; RT ; RL Submitted (21-DEC-2021) to the INSDC. RL ANTHONY NOLAN RESEARCH INSTITUTE, 77C Fleet Road, London, NW3 2QU, United RL Kingdom XX DR MD5; 7db717d66a285bce7228b759d130bd94. XX FH Key Location/Qualifiers FH FT source 1..14494 FT /organism="Homo sapiens" FT /mol_type="genomic DNA" FT /clone="AN300820" FT /db_xref="taxon:9606" FT CDS join(146..245,8503..8772,12231..12512,13210..13320, FT 13793..13816,14445..14458) FT /codon_start=1 FT /transl_table=1 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /product="MHC class II antigen" FT /function="antigen presenting molecule" FT /protein_id="CAH1028226.1" FT /translation="MVCLKFPGGSCMAALTVTLMVLSSPLALAGDTRPRFLEQVKHECH FT FFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRAAV FT DTYCRHNYGVGESFTVQRRVYPEVTVYPAKTQPLQHHNLLVCSVNGFYPGSIEVRWFRN FT GQEEKTGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSLTSPLTVEWRARSE FT SAQSKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS" FT exon 146..245 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=1 FT intron 246..8502 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=1 FT exon 8503..8772 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=2 FT intron 8773..12230 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=2 FT exon 12231..12512 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=3 FT intron 12513..13209 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=3 FT exon 13210..13320 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=4 FT intron 13321..13792 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=4 FT exon 13793..13816 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=5 FT intron 13817..14444 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=5 FT exon 14445..14458 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=6 XX SQ Sequence 14494 BP; 3869 A; 2932 C; 3282 G; 4411 T; 0 other; tccaacacta gattacccaa tccacgagca aggaaatcag taacttcttc cctataattt 60 ggaatgtggg tggagagggg tcatagttct ccctgagtga gactcacctg ctcctctggc 120 ccctggtcct gtcctgttct ccagcatggt gtgtctgaag ttccctggag gctcctgcat 180 ggcagctctg acagtgacac tgatggtgct gagctcccca ctggctttgg ctggggacac 240 ccgacgtaag tgcacattgt gggtgctgac ctactatggg gtggggaaaa aagggagttg 300 tgttaacatt gtgcccaggc catgtccctt aagaaagtgt gacattttct tcagggattg 360 cccatcttta tcatatggat cccaaattat ttccaccaca aatggaactt ggctacttgc 420 cctattcatg agactgtgta aagggccttt gtacaggcca tgttttactt taaatctcta 480 ccaataaaac ctttgcatca catgtcctca gggtctttag aggatttaga aataaggatg 540 ctaaaataaa ttcctcatac agcacttccc tttatcatgt tgacttatgt cagacgaaac 600 aaggttttgt tttgaaaatt ttgtgggagt caaaggaatt caaagggtct ctcctagacg 660 atcctgtgtt gtcctccaca ggacctgtgg tgttggcccc tcttcctcat atgtgaggat 720 gtacccagtg gcctccccat tgtttccttt cttttttttc tgaactccag tgtttataaa 780 gcctgtatcc ctgtagcata tgtaggttct ctgacagaag ttatacttag tgctctttct 840 ttcttatggg gaaaaatccc tggatctgaa actgacatct ttagtacttg gagtcaccct 900 acaggtaaag accatttatg aggtattcat tggtgcctcc tcttgatcgg tctctcagac 960 ccctgaatac ttggatactc ctcaagaact taaggcatcc tctgaaaaac tggcccagat 1020 tagtgcttat tattaatctt ttataacctt tctatacttg tttctcctgc atgctctaac 1080 tagacatgac agaagagatt caactaacat aggataaatt atatgaaatt ctatttttgt 1140 aagtcaaaaa tagtcaaata ccagaaaatt aataatgttc aaactatata ctctgtgtgg 1200 ggttaccgag acgacgtgga cattgttcac atctaatagg gctgaaagtc aatgaagaag 1260 tcctggaaac tccttgtctt actggggtct tgtcctaaat ttcataggtt cacccatcat 1320 gccctcagct ttccttaatt agccatgtct gcttatctct acctccagtt tctctctatt 1380 tttccccagc tatgttgtca tcatttccag aaatctctaa aacttgcaaa gatccttagc 1440 actatgagat ccattgaaag agataatttt tttctttttg agacagggct tggttctgtc 1500 acccaggctg tagtgcagtg gtgtgatcta ggctcactgc aacctctgct tcccacgctc 1560 aagtgatcct ccctcctcag cctccagagt agcggagact acaggcaggc aaacatgtgc 1620 agctaatttt catgattttg ttagagatga gattttgcca tgttgcccag gctgttctta 1680 aactcctgga ctcaagcaat cctcctgcct tagcctccca atatgctagg attatagatg 1740 tgagccattg tgcccaggca aaaagagatg aaccttaatt taaaaatttc ctttttctta 1800 aatcactgtt tctctatctg tgaattcttc ttccaactag aaggaggaga aagaagaagt 1860 ttgcctgtat ttctcaccag gaggaggagt ctagtgtgat atcaaaatga aagagtgctg 1920 gagcttgatc cccttcttgc tttccaggat ccctgcagtg atcagttccc acaccctggt 1980 ttattcatgt aaagcacact tatttttttc agcagctact ctttactggg ctccattcta 2040 agttcaaatc attctatttg agtaagatag agagggtccc gactctcatg gaagttacac 2100 aagagtagag gagacagaca ctaacccaat aagcatttaa caaagaagaa aatgttagag 2160 agacatagtg cactgaagaa aagacatcag gtttgtgaaa aagagagaca tggattcact 2220 tactttggtt catatgctta ggcagctata actgagaaag tgacattcag ctgagacaac 2280 aaaataaata gacagtcgtg aagatctaaa ggacgaaagt tccagggaga atgaatgggg 2340 gggaagctct ggtgtgggaa attatgtgga aggacagaaa gaaggctaga gggactgaac 2400 tatagcaagc aaggaaatgg agaggcagaa gatgaggtag gacacagaga ggaagtcagg 2460 agcctcatca tattagactc tgatggccat ggtaaaaaaa ttgaatttta ttttattttt 2520 atttattttt tgagacggag atttgttctt gttgcccagg ctggagtgca atggcgcgat 2580 ctcgactcac tgcaacctct gcctcctggg ttcaagtgat tctcctgcct cagcttccca 2640 agtagctggg attacaggtg cctgcgacca tactcggctt atttttttgt atttttagta 2700 gagacagggt atcaccatgt tggccaggct ggtctcaaac tcctgacctc agataatctg 2760 cctggcttcc caaagtgctg agattacagg cgtgagccac catgcccaac ctgaatttta 2820 tttgaataga tatgagaagc tactgtatgg ttacaaggac agtcaattta tattcgattt 2880 tttttttttg agacagagtc ttgctctgtt gcccaggcta gattgcagtg gtacaatctc 2940 agctcactgc aacctctgcc tcctgggttc cagcaattct cctgcctcag cctcccaagt 3000 agctgagacc acaggtacat gccactacac ctggctaatt ttttgtattt ttagtagaga 3060 tggggtttca ccgtgttagc caggatggtc ttgatctcct gacctcgtga tccactcccc 3120 tcggcctccc aaagtgctgg gattacaggt gtgagccacc acgcccggcc tatattcaat 3180 tattaaaatt aattctagct actctgtggg gattggattg ttgggtttca caagtggtca 3240 ggaagactat ttaggatcac agcagggaat tctccaggga aaacaggctt gtggcttcat 3300 agagtgcatt agtgataaag acagtgaaaa cgacaaagtg gacagactag gcatgtattt 3360 ttgcttagct tgttaatgga ttactctaaa gggggtagaa aaatcaagct tattcctaag 3420 gattttgttt tgacaaataa gtggatggtg gtgtttattg agataggaaa aactgtggga 3480 ggaaatgatt tgaagtgggt ggttggaaat aaaagttttg tttaaatttg agatgattta 3540 ttgacattta tgtggagcaa tccgaaggtc aatggcattt aagagactca tggtgaggtg 3600 aggccagggc ttcaggtatt tatgttggcg gcatcagtac gtgtaatgtg ttaaattcca 3660 gggagtggaa gaggatacat agggagatgg attgtgtgga gaaaaaagaa gagggtacag 3720 gccagcaaag ggggctgaga cagagcccag ggatgctgga gaaaacccaa gagaacataa 3780 tgggtgtaag tcatggaaaa tagattattt tcaaggagaa gggagaggtc aattgtggtg 3840 agtaccacta agaggagggg gaagtgagaa cgtgacagag aagcaagtgc tgggtttgct 3900 ggagttgata tttgcagtca atggagtatc cagggaggaa actggattgg accatttgaa 3960 gagcaagtag aagtgaggac gaggttaagg gtgactattt taagtagaga gcttcaggga 4020 aggactgtgc tctgggttca gggagcctgc tggatctaaa ggaaaagggc tgaagaggct 4080 gaagagaagg aggaggacct gtgaaccaga gatactgagt tattattagc aaggaaatac 4140 tagagggtcc ctgtgtgcag tgctgactgc tcatgcaaaa ggtcacacag acaatatttc 4200 acacagccag tatttattag tgacatagaa tatgccagtt attactctag gtcatgagaa 4260 tagagtgata aataaaatga atctggtcgc catcggtata tgccatgtaa cattttgcag 4320 tgactgtgta ccaggcctat gaatttcagt atgcaatttc aataacgatc ctgttgtatc 4380 tgtggtgttt aaaaacatat acatctctgg aatctaaaat tgagaggata taagtaaaac 4440 ccagtattag aaatttagtg ctggaaatca gactgcagtt taaatctgag catatagaaa 4500 gtccctttct tctatgtcag cagatgcctt ttgtgtgagg tttaggtata ctacattatt 4560 agacataaac cagtgattct gccctatgtt ttcagaatga caattcttta tgaaactaat 4620 agaagaacag aagacaattg caaaatcatg atgaagatgc tagtggcttt agaaccaagg 4680 aatacaaaaa ataatgtgag ctgcagttat agggattata aaagttaaaa tgggaatgca 4740 tttgagtgtt tattatgtga tcagtgctaa taagagtcat catttaattt tacacttaac 4800 aataatcctg tgaggattaa gctattatta aatgcatttg atagattaca aaaaggctta 4860 ccgttggtaa aaattgaccc aaggggaaga ggtcacattt ttattcagat tttctgattc 4920 tagagtttga gagtctgtcc atcattagtg agtagtgaca atactgtgtc taaattatcg 4980 acagaatttc tgatattcat atgtactatg ttgtttctta gagtgtgggc agagattcag 5040 ggctgctagt tccaatgtat aggagaaact ttcattcatt gtgcatttat cattttaaaa 5100 gttctaggct gggtgcggtg gctcatgcct gtaatcccag cactttggga ggccaaggcg 5160 ggcagatcac gaggtcagga gatgaagacc atcctggcta acatggtgaa acctcgtctc 5220 tactaaaaat acaaaaaatt agctgggcgt ggtggtgtgc acctgtagtc ccagctactt 5280 gggaggctga ggcaggagaa tggcatgaac ctgggaggcg gagcttgcag tgagctgaga 5340 tcgtgccact gcactccagc tccaccctgg gcaaaagagc gaaactccgt ctcaaaaaaa 5400 aaaaaaagtt ctatatgtct gtcatggcat atgttgaaga acacaaggaa gtattaaatc 5460 actccttctg aggtttgtct agcaagttgg gctaggattg ccaaataaaa tacaggtttc 5520 tagttaaatc tgaatttcag atacacaact ataatttact gaaaatccaa atgtaacttg 5580 gcatcctctg attttatttg ccaaatctgt caaccctaca tgagacacat gagcatggat 5640 tacggtgtta cccatggaag ccacagccac agtgacagcg acttcacaca tgtttatttt 5700 ttaactttct ctctgtaaag aaagtgctta gataatttag ggataaaaag atagacattg 5760 tttgatccag gatgcactcc tctctgccat cgtttctaaa gggcaaagag agatttccac 5820 aggtcttact cacagtctga ctcacagtct ggggacctgc tcatgctttg aaactgtctg 5880 tatgagaatg tcattttctt ggtttctccc tttctgaggg gacttgacta caaaactgag 5940 agttctacct ctggccaagg ctggaaattt gatgcctgct agtattgttg ggaatgggag 6000 actgaaataa atgagttagt tggggcatta aacaggaata aaatagctgt ggttgtgatt 6060 cattactaca attagtggac tagtggcaga gaaattaaga aagaagatga tgtgagagat 6120 aaattatatg atttggtaag gcaagggaat cagtaaatct tggttctgaa caagttcatt 6180 ttctggaaag atagcactgt actgggacca gaattctaca aaacatccgt tttatgtaag 6240 accaagattt tcaacaaata tttttcaatg cagttctcag ctgctccata actaatagtg 6300 acttattcaa cacagatatt ttcagatggt tcacacccat gtttcttacc cagggacagt 6360 tcaccacccc tccccttccc tcccatcact cttgaggaac atgtggcaat gttagaataa 6420 tttttggttg tcacaacagg ggtttcttct gatatttaat gagcagaagc cagggacact 6480 gctagagaac ccacaatgtt cagaatagac tccatcacca accaagattt atctcgtcca 6540 aaatgtcaat agtgctgagg ctggaagcat tggttcacac tgtgctcttt ctgaaaaatg 6600 tagactcgct tttttttttt ttttttttga gatggggtct tgctctgtcg cccagactgg 6660 agtgcagtgg ctccatctca gctcactaca acctctgcct cccaggttca agcgattctc 6720 ctgtctcagc ctccccagta gctgggatta caggtgcacc ctgccatgcc cggctaattt 6780 tttgtatttt agtagagatg gggtttcacc atgttgccca ggctggtctc gaactcctga 6840 gctcaggcaa tccacccgct ttggtctccc aaagtgctag gattacacgc atgagccacc 6900 gcgcccggcc tagactcaca tcttttatac acttactgcc caattcagtt ctttatggtt 6960 tatttttgct tgtttcatta taaaaaacta gacagttgca taaattcaac cacttacttg 7020 ttgaatccat ttagtcaatg caagctcaac attttcatat ttattttttg ccttatgcaa 7080 tattgttcaa cattttcata agttgttggt cagcactatc tctattaact ttcaacagtt 7140 tgcccttcta agtcacaaat agtgatgctg ctgcaattat ttttcactaa catgcctcag 7200 atttctgtag tgattctaca tttgatatta ttcacaatgt aaaatgcttc tatttattca 7260 tttcactttt acccacagga ttatttttaa gttatttttg tcattttcac acttcaacca 7320 aacataaaga caaaaacatc aaaaatatgt acatagtgtt atacataggt gtatatttac 7380 acacatatat gcacatatgt ttatatgtat tgaaactaca gaagcacatg tcaccaataa 7440 gagctctgag acacctttga ccacttaccc ttatcagatg agatttgcca aatgagtttt 7500 gggaacaaat ttcttttaac tgaatttctg agctttgtgg atttagaaat gcaactgaaa 7560 gtttgtggac atttacgagg atcatagttt tattctcctt aaaactcttc aatactttcc 7620 cattgtcttt agtaaatcca aaatcctaac accactcacg aggcttttca acacctggct 7680 tcttgtgatt tctccaatct aaccttttac cctccttccc ctcagcctct ctgctttagt 7740 gaactttgtt ctagtttttt gaagttcatc atcaattcaa gcttttgtac atgggatttc 7800 ctaaacctga aatgtgcctc cggttttgtc caaacagaca cacaggctcc actctgcccc 7860 ctggctcaca cctgcttaac ttgttaagtc acatctgtaa ctgtcactct tctctggcac 7920 cctaaaggaa ttgagatcat cctattattc tctgttctag aactccacac ttctgaaatt 7980 tctcattcct gtctaagctc ttgtgtgttt ggtttttggc catcactttc actgctctta 8040 aagctccccc agcggagtgg agaggtctgt tttcccgtgt ttggattcct agaggcagcg 8100 caggcctggc acaaggtcat cactaaggaa gtgttcacag gatgaaagcg gtgcgtgctg 8160 tttaaggaaa gggtaaagcc tttaaatggt aaagggttga gagaaggagc aaagtgcctt 8220 tggggtggag gctcccagga ggaggcggcg cgggctgcgg tgctggacgg atcctcctcc 8280 agctcctgcc tggaggtctc cagaacaggc tggaggcagg gagggggtcc caaaagcctt 8340 gggatcagag gtagtttttc cacctggtcc cccagacccc cgtccgcctc agaaagacag 8400 aggatgagcc cctgggctgc gtgttgtcgg ggttgcgggt ggggccagat agtgtcttcc 8460 ccggaggccg cttctgtaac cggatcgttc ttgtcccccc agcacgtttc ttggagcagg 8520 ttaaacatga gtgtcatttc ttcaacggga cggagcgggt gcggttcctg gacagatact 8580 tctatcacca agaggagtac gtgcgcttcg acagcgacgt gggggagtac cgggcggtga 8640 cggagctggg gcggcctgat gccgagtact ggaacagcca gaaggacctc ctggagcaga 8700 ggcgggccgc ggtggacacc tactgcagac acaactacgg ggttggtgag agcttcacag 8760 tgcagcggcg aggtgagcgc ggcgcggggc ggggcctgag tccctgtgag cggagaatct 8820 gagtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtga gagagagaga 8880 gagagagaga gagagagaga gcgccatctg tgagcattta gaatcctctc tatcctgagc 8940 aaggagttct gcgggcacag gtgtgtgtgt agagtgtgga tttgtccgtg tctgtgaggc 9000 tgttgtggga ggggaggcag gagggggctg cttcttattc ttggagactt ctgtggggag 9060 gtgacaaggg aggtgggtgc tgggggctgg agagagaggc gaccttgatt gtctcgggtc 9120 cttagagatg caaggaaggg aaatgtatgg ggtgtgtggt tggggtgaag gtttagggga 9180 ggagagctga ggggtaagga aggtttggga taatgtgaag aggccagttt cagactgtcc 9240 ctggcacaca cccttcatgt aatctctgaa ataaaagtgt gtgctgtttg tttgtaaaag 9300 cattagatta acttctaggg gaattgagta gacctctgag gcacctctga agcttcttta 9360 ggtataaatt tcttgctagt tttttgtttt cttagtgtta tatttttaca tagttgaaat 9420 gactgtgaaa ctaacttttt gaattaaagt ttgaaaacac tgttactatt ttattataat 9480 gctaataatt tcatagttac tttttaaata tataatagtt gtgacacaaa ttacctcact 9540 ttctttgttt ttttttttct tacactttaa gttttagggt acatgtgcac aacgtgcagg 9600 tttgttacat atgtatacat gtgccatgtt ggtgtgctgc acccattaac tcgtcattta 9660 acattaggta tatctcctaa tgctatccct ccccaccccc ccaccccaca acaggcccca 9720 gtgtgtgatg ttccccttcc tgtgtccatg tgttctcact gttcaattcc cacctatgag 9780 tgagaacatg cggtgttcgg ttttttgtcc ttgccatagt ttgctgagaa tgatggtttc 9840 cagcttcatc catgtcccta caaaggacat gaactcattc ttttttgtgg ctgcatagta 9900 ttccatagtg tatatgtgcc acattttctt aatccagtct atcattgttg gacatttggg 9960 ttggttccaa gtctttgcta ttgtgaatag tgccgcaata aacatacatg tgcatatgtc 10020 tttatagcag catgatttat aatccttggg ttatataccc agtaatggga tggctgggtc 10080 aaatggtatt tctagttcta gatccctgag gaatcgccac actgacttcc acaatggttg 10140 aactagttta gagtcccacc aacagggtaa aagtgttcct atttctccac atcctctcca 10200 gcacctgttg cttcctgact ttttaatgat cgccattcta actggtgtga gatggtatct 10260 cattgtggtt ttgatttgca attctctgat ggccagtgat gatgagcatt ttttcatgtg 10320 tcttttggct gcataaatgt cttcttttga gaagtgtctg ttcatgtcct ttgcccactt 10380 tttgatgggg tattttgttt ttttcttgta aatttgtttg agttcattgc agattctgga 10440 tattagccct ttgtcatatg agtagattgc aaaaattttc tcccattctg taggttgcct 10500 cttcactctg atggtagttt cttttgctgt gcagaagctc tttagtttaa ttagatccca 10560 tttgtccatt ttggcttttg ttgccattgc ttttggtgtt ttagacatga agttcttgcc 10620 catgcctatg tcctgaatgg tattgcctag gttttcttct agggttttta tggtttcagg 10680 tctaacattt aagtctttaa tccatcttga attaattttt gtataagcaa attacgtcac 10740 tttccccatt gatgaccttt attatgacat tcaccaatag ttgaaaatgt atgtttctgg 10800 ttaatttttg atttatattt ttttgatttg taattatttt gaattatttt gacctattta 10860 ttggccagtt gtaattactg ctctgctcta cgaattacct gttgtatttg gtaggtaatg 10920 gacaatgatc tattgtctct tatctttagg gcttagtatt tttctcagtg actttgtggg 10980 tttgttgtac tgtaagatta ttaacacttt attgatattt gattcagtat tttctccagt 11040 ttgtggtatg tatattttga aaattctttt ccatgttaag aatttgaaca tttttattta 11100 ataaaatata ttgcaaaatg ttaattaatg attcacaaac tagctcaagt ctaccatttt 11160 gtggtattga tgtctccagg tttctccttc cttcttaaaa aaaaatgtat ttattgagag 11220 tatgctagtg tcagggattt ccctaggcat aagcactcca agtaatgagt cccagacact 11280 gccttgatcc aaatgtcatt ctggaaagaa aaatcatttt acagtgataa gcctaataat 11340 agttatactt gttttgcctg ggagatgcat tgatcagcta aatgtaaata taagaacttt 11400 caaaactaaa atgacgttcc ttaatctttc tctctgcttt aggaatcatg ctttcttagg 11460 aacttaaaga tttggagaat catttctgtc tgtcccacct tcccaggagc ataaccattt 11520 ctgtggtgtt ctaaggtgtg agtgcatggc agtagtattc ctaaaaatcc atattcagtt 11580 tcctcatgtg ccctactccg tccctttctc tatccacatt gctttaaatc atatttttct 11640 ctcaaggtgt acaaggatga taaataggtg ccaagtggag aacccaagtg tgacgagccc 11700 tctcacagta gaatggagtg agaagctttc tgacctcata aattgaaggc tatcgtaatt 11760 cattctttta tatattttac ttgcattaat cctcatataa cctcaagagg taaattaata 11820 taattatcct ccattattgg agagaaagtt gagacacaaa agaatcaaaa actcttccag 11880 gatcaaccag taaaaggcag accttggatt tgaaccaggc aacctggctc agaagtcagt 11940 tttaattacc acactctgta ctttcaaaga tttgtaaacg ctttgacaat gcatgtcaat 12000 ttcaagctat gaagagccaa acataatttt tcacaatatc tctcaaatct aatgggtccc 12060 cactataaag attaaattcc aggctgatga cactgtgagg ccacatggcc agctgtgctg 12120 gaggcctgct caaggccaga gcctaggttt acagagaagc agacaaaaag ctaaacaagg 12180 agacttactc tgtctgcatg acttattccc tctaccttgt tttctcctag tctatcctga 12240 ggtgactgtg tatcctgcaa agacccagcc cctgcagcac cacaacctcc tggtctgctc 12300 tgtgaatggt ttctatccag gcagcattga agtcaggtgg ttccggaacg gccaggaaga 12360 gaagactggg gtggtgtcca caggcctgat ccagaatgga gactggacct tccagaccct 12420 ggtgatgctg gaaacagttc ctcggagtgg agaggtttac acctgccaag tggagcaccc 12480 aagcctgacg agccctctca cagtggaatg gagtgagcag ctttctgact tcataaattt 12540 ctcacccacc aagacgcgaa ctttactaat ccctgagtat caggcttctc ctatcccaca 12600 tcctattttc atttgctcca cgttctcatc tccatcagca caggtcactg gggggtagcc 12660 ctgtaatact ttctagaaac acctgtaccc cctggggaag cagtcatgcc tgccaggcag 12720 gagaggctgt ccctcttttg aacctcccca tgatgtcaca agtcggggtc acctgctgtc 12780 tgtgggctcc aggccctgcc tctgggtctg agactgagtt tctggtactg ttgctctgag 12840 tcgtttgttg taatctgaga agaggagaag tatagggacc ttcctgacat gaggggagtc 12900 caatctcagc tccgcctttt attagatctg tcactctagg caactactta acctcattgg 12960 gtctcaggct ttctgttcat cagatgttga agtcctgtct tacatcaagg ctgtaatatt 13020 tgaatgagtt tgatgactga accttgtaac tgttcagtgt gatttgaaaa cctttctcaa 13080 gaaatggtca gttattttag ttcttgcaga gcagccttct ttctcatttt caaagctctg 13140 aatctcaagg tgtcaattaa agaggttcca tttgggataa aaatcactaa acctggcttc 13200 ctctctcagg agcacggtct gaatctgcac agagcaagat gctgagtgga gtcgggggct 13260 tcgtgctggg cctgctcttc cttggggccg ggctgttcat ctacttcagg aatcagaaag 13320 gtgaggagcc tttggtagct ggctgtctcc atacgctttt ctggaggagg aactatggct 13380 ttgctgaagt tggttctcag catatgaatg gccctggata aagcctctct actcccaaat 13440 gacctccaat gttctgcaaa tccagaaatc atcagtgcat ggttgctatg tcaaagcata 13500 atagcttgtg gcctacagag ataacagaaa gattaacagg tataggtgct ttggttgaga 13560 tcgtggagca aattaaggaa gagcaactaa agctaataca attacactgg atcctgtgac 13620 agacacttca cacttcatgg gtcacatggt ctgtttctgc tcctctctgc cctggctggt 13680 gtgggttgtg gtgtcagaga actctcaggt gggagatctg gagctgggac attgtgttgg 13740 aggacagatt tgcttccata tcctttaagt gtatatcttc tctttttcct aggacactct 13800 ggacttcagc caacaggtaa taccttttca tcctctttaa gaaacagatt tggaggccag 13860 gcgcagtggc tcacgcctgt aatcccagca ctttgggagg ccgaggcggg cgaatcatga 13920 ggtcaggagt tcgagaccag cctgaccaac gtggtgaaac cccgtctcta ctaaaaatac 13980 aaaaaaaaat cagtcgggcg tggtggtgtg cgcctgtaat cccagctact caggaggcca 14040 aggcaggaga atcgctggaa cccaggaggc agaggttgca gtgagccgag attgggccac 14100 tgcactccag cctaggtgac agagtgagac cccatctcaa aaaaacaaaa aaaagaaaga 14160 aagaaacaga tttcctttcc ctagaatgat ggtagaggta ataaggcatg agacagaagt 14220 aatagcaaag acattggatc caaatttctg atcaggcaat ttacaccaga actcctcctc 14280 tccacttaga aaaggcctgt gctctgcagg agtattgact catggagact tcagaacttg 14340 tttttcttct tcctgcagtg ctctcatctg agtccttgaa agagggcaaa ataaactgtt 14400 agtagagcca ggtctgaaaa caacactttc ttgcgtctct gcaggattcc tgagctgaag 14460 tgaagatgac cacattcaag gaagaacctt ctgc 14494 // ID OV305435; SV 1; linear; genomic DNA; STD; HUM; 14494 BP. XX AC OV305435; XX PR Project:PRJEB49636; XX DT 06-JAN-2022 (Rel. 144, Created) DT 06-JAN-2022 (Rel. 144, Last updated, Version 1) XX DE Homo sapiens HLA-DRB1 gene for MHC class II antigen, allele DE HLA-DRB1*04:08:01 XX KW . XX OS Homo sapiens (human) OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. XX RN [1] RA Lucas J., Lucas AM J.; RT ; RL Submitted (21-DEC-2021) to the INSDC. RL ANTHONY NOLAN RESEARCH INSTITUTE, 77C Fleet Road, London, NW3 2QU, United RL Kingdom XX DR MD5; 7db717d66a285bce7228b759d130bd94. XX FH Key Location/Qualifiers FH FT source 1..14494 FT /organism="Homo sapiens" FT /mol_type="genomic DNA" FT /clone="AN300821" FT /db_xref="taxon:9606" FT CDS join(146..245,8503..8772,12231..12512,13210..13320, FT 13793..13816,14445..14458) FT /codon_start=1 FT /transl_table=1 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /product="MHC class II antigen" FT /function="antigen presenting molecule" FT /protein_id="CAH1028227.1" FT /translation="MVCLKFPGGSCMAALTVTLMVLSSPLALAGDTRPRFLEQVKHECH FT FFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRAAV FT DTYCRHNYGVGESFTVQRRVYPEVTVYPAKTQPLQHHNLLVCSVNGFYPGSIEVRWFRN FT GQEEKTGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSLTSPLTVEWRARSE FT SAQSKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS" FT exon 146..245 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=1 FT intron 246..8502 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=1 FT exon 8503..8772 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=2 FT intron 8773..12230 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=2 FT exon 12231..12512 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=3 FT intron 12513..13209 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=3 FT exon 13210..13320 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=4 FT intron 13321..13792 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=4 FT exon 13793..13816 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=5 FT intron 13817..14444 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=5 FT exon 14445..14458 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:08:01" FT /number=6 XX SQ Sequence 14494 BP; 3869 A; 2932 C; 3282 G; 4411 T; 0 other; tccaacacta gattacccaa tccacgagca aggaaatcag taacttcttc cctataattt 60 ggaatgtggg tggagagggg tcatagttct ccctgagtga gactcacctg ctcctctggc 120 ccctggtcct gtcctgttct ccagcatggt gtgtctgaag ttccctggag gctcctgcat 180 ggcagctctg acagtgacac tgatggtgct gagctcccca ctggctttgg ctggggacac 240 ccgacgtaag tgcacattgt gggtgctgac ctactatggg gtggggaaaa aagggagttg 300 tgttaacatt gtgcccaggc catgtccctt aagaaagtgt gacattttct tcagggattg 360 cccatcttta tcatatggat cccaaattat ttccaccaca aatggaactt ggctacttgc 420 cctattcatg agactgtgta aagggccttt gtacaggcca tgttttactt taaatctcta 480 ccaataaaac ctttgcatca catgtcctca gggtctttag aggatttaga aataaggatg 540 ctaaaataaa ttcctcatac agcacttccc tttatcatgt tgacttatgt cagacgaaac 600 aaggttttgt tttgaaaatt ttgtgggagt caaaggaatt caaagggtct ctcctagacg 660 atcctgtgtt gtcctccaca ggacctgtgg tgttggcccc tcttcctcat atgtgaggat 720 gtacccagtg gcctccccat tgtttccttt cttttttttc tgaactccag tgtttataaa 780 gcctgtatcc ctgtagcata tgtaggttct ctgacagaag ttatacttag tgctctttct 840 ttcttatggg gaaaaatccc tggatctgaa actgacatct ttagtacttg gagtcaccct 900 acaggtaaag accatttatg aggtattcat tggtgcctcc tcttgatcgg tctctcagac 960 ccctgaatac ttggatactc ctcaagaact taaggcatcc tctgaaaaac tggcccagat 1020 tagtgcttat tattaatctt ttataacctt tctatacttg tttctcctgc atgctctaac 1080 tagacatgac agaagagatt caactaacat aggataaatt atatgaaatt ctatttttgt 1140 aagtcaaaaa tagtcaaata ccagaaaatt aataatgttc aaactatata ctctgtgtgg 1200 ggttaccgag acgacgtgga cattgttcac atctaatagg gctgaaagtc aatgaagaag 1260 tcctggaaac tccttgtctt actggggtct tgtcctaaat ttcataggtt cacccatcat 1320 gccctcagct ttccttaatt agccatgtct gcttatctct acctccagtt tctctctatt 1380 tttccccagc tatgttgtca tcatttccag aaatctctaa aacttgcaaa gatccttagc 1440 actatgagat ccattgaaag agataatttt tttctttttg agacagggct tggttctgtc 1500 acccaggctg tagtgcagtg gtgtgatcta ggctcactgc aacctctgct tcccacgctc 1560 aagtgatcct ccctcctcag cctccagagt agcggagact acaggcaggc aaacatgtgc 1620 agctaatttt catgattttg ttagagatga gattttgcca tgttgcccag gctgttctta 1680 aactcctgga ctcaagcaat cctcctgcct tagcctccca atatgctagg attatagatg 1740 tgagccattg tgcccaggca aaaagagatg aaccttaatt taaaaatttc ctttttctta 1800 aatcactgtt tctctatctg tgaattcttc ttccaactag aaggaggaga aagaagaagt 1860 ttgcctgtat ttctcaccag gaggaggagt ctagtgtgat atcaaaatga aagagtgctg 1920 gagcttgatc cccttcttgc tttccaggat ccctgcagtg atcagttccc acaccctggt 1980 ttattcatgt aaagcacact tatttttttc agcagctact ctttactggg ctccattcta 2040 agttcaaatc attctatttg agtaagatag agagggtccc gactctcatg gaagttacac 2100 aagagtagag gagacagaca ctaacccaat aagcatttaa caaagaagaa aatgttagag 2160 agacatagtg cactgaagaa aagacatcag gtttgtgaaa aagagagaca tggattcact 2220 tactttggtt catatgctta ggcagctata actgagaaag tgacattcag ctgagacaac 2280 aaaataaata gacagtcgtg aagatctaaa ggacgaaagt tccagggaga atgaatgggg 2340 gggaagctct ggtgtgggaa attatgtgga aggacagaaa gaaggctaga gggactgaac 2400 tatagcaagc aaggaaatgg agaggcagaa gatgaggtag gacacagaga ggaagtcagg 2460 agcctcatca tattagactc tgatggccat ggtaaaaaaa ttgaatttta ttttattttt 2520 atttattttt tgagacggag atttgttctt gttgcccagg ctggagtgca atggcgcgat 2580 ctcgactcac tgcaacctct gcctcctggg ttcaagtgat tctcctgcct cagcttccca 2640 agtagctggg attacaggtg cctgcgacca tactcggctt atttttttgt atttttagta 2700 gagacagggt atcaccatgt tggccaggct ggtctcaaac tcctgacctc agataatctg 2760 cctggcttcc caaagtgctg agattacagg cgtgagccac catgcccaac ctgaatttta 2820 tttgaataga tatgagaagc tactgtatgg ttacaaggac agtcaattta tattcgattt 2880 tttttttttg agacagagtc ttgctctgtt gcccaggcta gattgcagtg gtacaatctc 2940 agctcactgc aacctctgcc tcctgggttc cagcaattct cctgcctcag cctcccaagt 3000 agctgagacc acaggtacat gccactacac ctggctaatt ttttgtattt ttagtagaga 3060 tggggtttca ccgtgttagc caggatggtc ttgatctcct gacctcgtga tccactcccc 3120 tcggcctccc aaagtgctgg gattacaggt gtgagccacc acgcccggcc tatattcaat 3180 tattaaaatt aattctagct actctgtggg gattggattg ttgggtttca caagtggtca 3240 ggaagactat ttaggatcac agcagggaat tctccaggga aaacaggctt gtggcttcat 3300 agagtgcatt agtgataaag acagtgaaaa cgacaaagtg gacagactag gcatgtattt 3360 ttgcttagct tgttaatgga ttactctaaa gggggtagaa aaatcaagct tattcctaag 3420 gattttgttt tgacaaataa gtggatggtg gtgtttattg agataggaaa aactgtggga 3480 ggaaatgatt tgaagtgggt ggttggaaat aaaagttttg tttaaatttg agatgattta 3540 ttgacattta tgtggagcaa tccgaaggtc aatggcattt aagagactca tggtgaggtg 3600 aggccagggc ttcaggtatt tatgttggcg gcatcagtac gtgtaatgtg ttaaattcca 3660 gggagtggaa gaggatacat agggagatgg attgtgtgga gaaaaaagaa gagggtacag 3720 gccagcaaag ggggctgaga cagagcccag ggatgctgga gaaaacccaa gagaacataa 3780 tgggtgtaag tcatggaaaa tagattattt tcaaggagaa gggagaggtc aattgtggtg 3840 agtaccacta agaggagggg gaagtgagaa cgtgacagag aagcaagtgc tgggtttgct 3900 ggagttgata tttgcagtca atggagtatc cagggaggaa actggattgg accatttgaa 3960 gagcaagtag aagtgaggac gaggttaagg gtgactattt taagtagaga gcttcaggga 4020 aggactgtgc tctgggttca gggagcctgc tggatctaaa ggaaaagggc tgaagaggct 4080 gaagagaagg aggaggacct gtgaaccaga gatactgagt tattattagc aaggaaatac 4140 tagagggtcc ctgtgtgcag tgctgactgc tcatgcaaaa ggtcacacag acaatatttc 4200 acacagccag tatttattag tgacatagaa tatgccagtt attactctag gtcatgagaa 4260 tagagtgata aataaaatga atctggtcgc catcggtata tgccatgtaa cattttgcag 4320 tgactgtgta ccaggcctat gaatttcagt atgcaatttc aataacgatc ctgttgtatc 4380 tgtggtgttt aaaaacatat acatctctgg aatctaaaat tgagaggata taagtaaaac 4440 ccagtattag aaatttagtg ctggaaatca gactgcagtt taaatctgag catatagaaa 4500 gtccctttct tctatgtcag cagatgcctt ttgtgtgagg tttaggtata ctacattatt 4560 agacataaac cagtgattct gccctatgtt ttcagaatga caattcttta tgaaactaat 4620 agaagaacag aagacaattg caaaatcatg atgaagatgc tagtggcttt agaaccaagg 4680 aatacaaaaa ataatgtgag ctgcagttat agggattata aaagttaaaa tgggaatgca 4740 tttgagtgtt tattatgtga tcagtgctaa taagagtcat catttaattt tacacttaac 4800 aataatcctg tgaggattaa gctattatta aatgcatttg atagattaca aaaaggctta 4860 ccgttggtaa aaattgaccc aaggggaaga ggtcacattt ttattcagat tttctgattc 4920 tagagtttga gagtctgtcc atcattagtg agtagtgaca atactgtgtc taaattatcg 4980 acagaatttc tgatattcat atgtactatg ttgtttctta gagtgtgggc agagattcag 5040 ggctgctagt tccaatgtat aggagaaact ttcattcatt gtgcatttat cattttaaaa 5100 gttctaggct gggtgcggtg gctcatgcct gtaatcccag cactttggga ggccaaggcg 5160 ggcagatcac gaggtcagga gatgaagacc atcctggcta acatggtgaa acctcgtctc 5220 tactaaaaat acaaaaaatt agctgggcgt ggtggtgtgc acctgtagtc ccagctactt 5280 gggaggctga ggcaggagaa tggcatgaac ctgggaggcg gagcttgcag tgagctgaga 5340 tcgtgccact gcactccagc tccaccctgg gcaaaagagc gaaactccgt ctcaaaaaaa 5400 aaaaaaagtt ctatatgtct gtcatggcat atgttgaaga acacaaggaa gtattaaatc 5460 actccttctg aggtttgtct agcaagttgg gctaggattg ccaaataaaa tacaggtttc 5520 tagttaaatc tgaatttcag atacacaact ataatttact gaaaatccaa atgtaacttg 5580 gcatcctctg attttatttg ccaaatctgt caaccctaca tgagacacat gagcatggat 5640 tacggtgtta cccatggaag ccacagccac agtgacagcg acttcacaca tgtttatttt 5700 ttaactttct ctctgtaaag aaagtgctta gataatttag ggataaaaag atagacattg 5760 tttgatccag gatgcactcc tctctgccat cgtttctaaa gggcaaagag agatttccac 5820 aggtcttact cacagtctga ctcacagtct ggggacctgc tcatgctttg aaactgtctg 5880 tatgagaatg tcattttctt ggtttctccc tttctgaggg gacttgacta caaaactgag 5940 agttctacct ctggccaagg ctggaaattt gatgcctgct agtattgttg ggaatgggag 6000 actgaaataa atgagttagt tggggcatta aacaggaata aaatagctgt ggttgtgatt 6060 cattactaca attagtggac tagtggcaga gaaattaaga aagaagatga tgtgagagat 6120 aaattatatg atttggtaag gcaagggaat cagtaaatct tggttctgaa caagttcatt 6180 ttctggaaag atagcactgt actgggacca gaattctaca aaacatccgt tttatgtaag 6240 accaagattt tcaacaaata tttttcaatg cagttctcag ctgctccata actaatagtg 6300 acttattcaa cacagatatt ttcagatggt tcacacccat gtttcttacc cagggacagt 6360 tcaccacccc tccccttccc tcccatcact cttgaggaac atgtggcaat gttagaataa 6420 tttttggttg tcacaacagg ggtttcttct gatatttaat gagcagaagc cagggacact 6480 gctagagaac ccacaatgtt cagaatagac tccatcacca accaagattt atctcgtcca 6540 aaatgtcaat agtgctgagg ctggaagcat tggttcacac tgtgctcttt ctgaaaaatg 6600 tagactcgct tttttttttt ttttttttga gatggggtct tgctctgtcg cccagactgg 6660 agtgcagtgg ctccatctca gctcactaca acctctgcct cccaggttca agcgattctc 6720 ctgtctcagc ctccccagta gctgggatta caggtgcacc ctgccatgcc cggctaattt 6780 tttgtatttt agtagagatg gggtttcacc atgttgccca ggctggtctc gaactcctga 6840 gctcaggcaa tccacccgct ttggtctccc aaagtgctag gattacacgc atgagccacc 6900 gcgcccggcc tagactcaca tcttttatac acttactgcc caattcagtt ctttatggtt 6960 tatttttgct tgtttcatta taaaaaacta gacagttgca taaattcaac cacttacttg 7020 ttgaatccat ttagtcaatg caagctcaac attttcatat ttattttttg ccttatgcaa 7080 tattgttcaa cattttcata agttgttggt cagcactatc tctattaact ttcaacagtt 7140 tgcccttcta agtcacaaat agtgatgctg ctgcaattat ttttcactaa catgcctcag 7200 atttctgtag tgattctaca tttgatatta ttcacaatgt aaaatgcttc tatttattca 7260 tttcactttt acccacagga ttatttttaa gttatttttg tcattttcac acttcaacca 7320 aacataaaga caaaaacatc aaaaatatgt acatagtgtt atacataggt gtatatttac 7380 acacatatat gcacatatgt ttatatgtat tgaaactaca gaagcacatg tcaccaataa 7440 gagctctgag acacctttga ccacttaccc ttatcagatg agatttgcca aatgagtttt 7500 gggaacaaat ttcttttaac tgaatttctg agctttgtgg atttagaaat gcaactgaaa 7560 gtttgtggac atttacgagg atcatagttt tattctcctt aaaactcttc aatactttcc 7620 cattgtcttt agtaaatcca aaatcctaac accactcacg aggcttttca acacctggct 7680 tcttgtgatt tctccaatct aaccttttac cctccttccc ctcagcctct ctgctttagt 7740 gaactttgtt ctagtttttt gaagttcatc atcaattcaa gcttttgtac atgggatttc 7800 ctaaacctga aatgtgcctc cggttttgtc caaacagaca cacaggctcc actctgcccc 7860 ctggctcaca cctgcttaac ttgttaagtc acatctgtaa ctgtcactct tctctggcac 7920 cctaaaggaa ttgagatcat cctattattc tctgttctag aactccacac ttctgaaatt 7980 tctcattcct gtctaagctc ttgtgtgttt ggtttttggc catcactttc actgctctta 8040 aagctccccc agcggagtgg agaggtctgt tttcccgtgt ttggattcct agaggcagcg 8100 caggcctggc acaaggtcat cactaaggaa gtgttcacag gatgaaagcg gtgcgtgctg 8160 tttaaggaaa gggtaaagcc tttaaatggt aaagggttga gagaaggagc aaagtgcctt 8220 tggggtggag gctcccagga ggaggcggcg cgggctgcgg tgctggacgg atcctcctcc 8280 agctcctgcc tggaggtctc cagaacaggc tggaggcagg gagggggtcc caaaagcctt 8340 gggatcagag gtagtttttc cacctggtcc cccagacccc cgtccgcctc agaaagacag 8400 aggatgagcc cctgggctgc gtgttgtcgg ggttgcgggt ggggccagat agtgtcttcc 8460 ccggaggccg cttctgtaac cggatcgttc ttgtcccccc agcacgtttc ttggagcagg 8520 ttaaacatga gtgtcatttc ttcaacggga cggagcgggt gcggttcctg gacagatact 8580 tctatcacca agaggagtac gtgcgcttcg acagcgacgt gggggagtac cgggcggtga 8640 cggagctggg gcggcctgat gccgagtact ggaacagcca gaaggacctc ctggagcaga 8700 ggcgggccgc ggtggacacc tactgcagac acaactacgg ggttggtgag agcttcacag 8760 tgcagcggcg aggtgagcgc ggcgcggggc ggggcctgag tccctgtgag cggagaatct 8820 gagtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtga gagagagaga 8880 gagagagaga gagagagaga gcgccatctg tgagcattta gaatcctctc tatcctgagc 8940 aaggagttct gcgggcacag gtgtgtgtgt agagtgtgga tttgtccgtg tctgtgaggc 9000 tgttgtggga ggggaggcag gagggggctg cttcttattc ttggagactt ctgtggggag 9060 gtgacaaggg aggtgggtgc tgggggctgg agagagaggc gaccttgatt gtctcgggtc 9120 cttagagatg caaggaaggg aaatgtatgg ggtgtgtggt tggggtgaag gtttagggga 9180 ggagagctga ggggtaagga aggtttggga taatgtgaag aggccagttt cagactgtcc 9240 ctggcacaca cccttcatgt aatctctgaa ataaaagtgt gtgctgtttg tttgtaaaag 9300 cattagatta acttctaggg gaattgagta gacctctgag gcacctctga agcttcttta 9360 ggtataaatt tcttgctagt tttttgtttt cttagtgtta tatttttaca tagttgaaat 9420 gactgtgaaa ctaacttttt gaattaaagt ttgaaaacac tgttactatt ttattataat 9480 gctaataatt tcatagttac tttttaaata tataatagtt gtgacacaaa ttacctcact 9540 ttctttgttt ttttttttct tacactttaa gttttagggt acatgtgcac aacgtgcagg 9600 tttgttacat atgtatacat gtgccatgtt ggtgtgctgc acccattaac tcgtcattta 9660 acattaggta tatctcctaa tgctatccct ccccaccccc ccaccccaca acaggcccca 9720 gtgtgtgatg ttccccttcc tgtgtccatg tgttctcact gttcaattcc cacctatgag 9780 tgagaacatg cggtgttcgg ttttttgtcc ttgccatagt ttgctgagaa tgatggtttc 9840 cagcttcatc catgtcccta caaaggacat gaactcattc ttttttgtgg ctgcatagta 9900 ttccatagtg tatatgtgcc acattttctt aatccagtct atcattgttg gacatttggg 9960 ttggttccaa gtctttgcta ttgtgaatag tgccgcaata aacatacatg tgcatatgtc 10020 tttatagcag catgatttat aatccttggg ttatataccc agtaatggga tggctgggtc 10080 aaatggtatt tctagttcta gatccctgag gaatcgccac actgacttcc acaatggttg 10140 aactagttta gagtcccacc aacagggtaa aagtgttcct atttctccac atcctctcca 10200 gcacctgttg cttcctgact ttttaatgat cgccattcta actggtgtga gatggtatct 10260 cattgtggtt ttgatttgca attctctgat ggccagtgat gatgagcatt ttttcatgtg 10320 tcttttggct gcataaatgt cttcttttga gaagtgtctg ttcatgtcct ttgcccactt 10380 tttgatgggg tattttgttt ttttcttgta aatttgtttg agttcattgc agattctgga 10440 tattagccct ttgtcatatg agtagattgc aaaaattttc tcccattctg taggttgcct 10500 cttcactctg atggtagttt cttttgctgt gcagaagctc tttagtttaa ttagatccca 10560 tttgtccatt ttggcttttg ttgccattgc ttttggtgtt ttagacatga agttcttgcc 10620 catgcctatg tcctgaatgg tattgcctag gttttcttct agggttttta tggtttcagg 10680 tctaacattt aagtctttaa tccatcttga attaattttt gtataagcaa attacgtcac 10740 tttccccatt gatgaccttt attatgacat tcaccaatag ttgaaaatgt atgtttctgg 10800 ttaatttttg atttatattt ttttgatttg taattatttt gaattatttt gacctattta 10860 ttggccagtt gtaattactg ctctgctcta cgaattacct gttgtatttg gtaggtaatg 10920 gacaatgatc tattgtctct tatctttagg gcttagtatt tttctcagtg actttgtggg 10980 tttgttgtac tgtaagatta ttaacacttt attgatattt gattcagtat tttctccagt 11040 ttgtggtatg tatattttga aaattctttt ccatgttaag aatttgaaca tttttattta 11100 ataaaatata ttgcaaaatg ttaattaatg attcacaaac tagctcaagt ctaccatttt 11160 gtggtattga tgtctccagg tttctccttc cttcttaaaa aaaaatgtat ttattgagag 11220 tatgctagtg tcagggattt ccctaggcat aagcactcca agtaatgagt cccagacact 11280 gccttgatcc aaatgtcatt ctggaaagaa aaatcatttt acagtgataa gcctaataat 11340 agttatactt gttttgcctg ggagatgcat tgatcagcta aatgtaaata taagaacttt 11400 caaaactaaa atgacgttcc ttaatctttc tctctgcttt aggaatcatg ctttcttagg 11460 aacttaaaga tttggagaat catttctgtc tgtcccacct tcccaggagc ataaccattt 11520 ctgtggtgtt ctaaggtgtg agtgcatggc agtagtattc ctaaaaatcc atattcagtt 11580 tcctcatgtg ccctactccg tccctttctc tatccacatt gctttaaatc atatttttct 11640 ctcaaggtgt acaaggatga taaataggtg ccaagtggag aacccaagtg tgacgagccc 11700 tctcacagta gaatggagtg agaagctttc tgacctcata aattgaaggc tatcgtaatt 11760 cattctttta tatattttac ttgcattaat cctcatataa cctcaagagg taaattaata 11820 taattatcct ccattattgg agagaaagtt gagacacaaa agaatcaaaa actcttccag 11880 gatcaaccag taaaaggcag accttggatt tgaaccaggc aacctggctc agaagtcagt 11940 tttaattacc acactctgta ctttcaaaga tttgtaaacg ctttgacaat gcatgtcaat 12000 ttcaagctat gaagagccaa acataatttt tcacaatatc tctcaaatct aatgggtccc 12060 cactataaag attaaattcc aggctgatga cactgtgagg ccacatggcc agctgtgctg 12120 gaggcctgct caaggccaga gcctaggttt acagagaagc agacaaaaag ctaaacaagg 12180 agacttactc tgtctgcatg acttattccc tctaccttgt tttctcctag tctatcctga 12240 ggtgactgtg tatcctgcaa agacccagcc cctgcagcac cacaacctcc tggtctgctc 12300 tgtgaatggt ttctatccag gcagcattga agtcaggtgg ttccggaacg gccaggaaga 12360 gaagactggg gtggtgtcca caggcctgat ccagaatgga gactggacct tccagaccct 12420 ggtgatgctg gaaacagttc ctcggagtgg agaggtttac acctgccaag tggagcaccc 12480 aagcctgacg agccctctca cagtggaatg gagtgagcag ctttctgact tcataaattt 12540 ctcacccacc aagacgcgaa ctttactaat ccctgagtat caggcttctc ctatcccaca 12600 tcctattttc atttgctcca cgttctcatc tccatcagca caggtcactg gggggtagcc 12660 ctgtaatact ttctagaaac acctgtaccc cctggggaag cagtcatgcc tgccaggcag 12720 gagaggctgt ccctcttttg aacctcccca tgatgtcaca agtcggggtc acctgctgtc 12780 tgtgggctcc aggccctgcc tctgggtctg agactgagtt tctggtactg ttgctctgag 12840 tcgtttgttg taatctgaga agaggagaag tatagggacc ttcctgacat gaggggagtc 12900 caatctcagc tccgcctttt attagatctg tcactctagg caactactta acctcattgg 12960 gtctcaggct ttctgttcat cagatgttga agtcctgtct tacatcaagg ctgtaatatt 13020 tgaatgagtt tgatgactga accttgtaac tgttcagtgt gatttgaaaa cctttctcaa 13080 gaaatggtca gttattttag ttcttgcaga gcagccttct ttctcatttt caaagctctg 13140 aatctcaagg tgtcaattaa agaggttcca tttgggataa aaatcactaa acctggcttc 13200 ctctctcagg agcacggtct gaatctgcac agagcaagat gctgagtgga gtcgggggct 13260 tcgtgctggg cctgctcttc cttggggccg ggctgttcat ctacttcagg aatcagaaag 13320 gtgaggagcc tttggtagct ggctgtctcc atacgctttt ctggaggagg aactatggct 13380 ttgctgaagt tggttctcag catatgaatg gccctggata aagcctctct actcccaaat 13440 gacctccaat gttctgcaaa tccagaaatc atcagtgcat ggttgctatg tcaaagcata 13500 atagcttgtg gcctacagag ataacagaaa gattaacagg tataggtgct ttggttgaga 13560 tcgtggagca aattaaggaa gagcaactaa agctaataca attacactgg atcctgtgac 13620 agacacttca cacttcatgg gtcacatggt ctgtttctgc tcctctctgc cctggctggt 13680 gtgggttgtg gtgtcagaga actctcaggt gggagatctg gagctgggac attgtgttgg 13740 aggacagatt tgcttccata tcctttaagt gtatatcttc tctttttcct aggacactct 13800 ggacttcagc caacaggtaa taccttttca tcctctttaa gaaacagatt tggaggccag 13860 gcgcagtggc tcacgcctgt aatcccagca ctttgggagg ccgaggcggg cgaatcatga 13920 ggtcaggagt tcgagaccag cctgaccaac gtggtgaaac cccgtctcta ctaaaaatac 13980 aaaaaaaaat cagtcgggcg tggtggtgtg cgcctgtaat cccagctact caggaggcca 14040 aggcaggaga atcgctggaa cccaggaggc agaggttgca gtgagccgag attgggccac 14100 tgcactccag cctaggtgac agagtgagac cccatctcaa aaaaacaaaa aaaagaaaga 14160 aagaaacaga tttcctttcc ctagaatgat ggtagaggta ataaggcatg agacagaagt 14220 aatagcaaag acattggatc caaatttctg atcaggcaat ttacaccaga actcctcctc 14280 tccacttaga aaaggcctgt gctctgcagg agtattgact catggagact tcagaacttg 14340 tttttcttct tcctgcagtg ctctcatctg agtccttgaa agagggcaaa ataaactgtt 14400 agtagagcca ggtctgaaaa caacactttc ttgcgtctct gcaggattcc tgagctgaag 14460 tgaagatgac cacattcaag gaagaacctt ctgc 14494 //